Results 61 to 70 of about 685,305 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fragility Curves of the Urban Road Network Based on the Debris Distributions of Interfering Buildings

Applied Sciences, 2020
Fragility curves are essential tools to quantitatively assess the physical vulnerability of structures and infrastructures at risk for a given seismic hazard.
Angelo Anelli, Federico Mori, Marco Vona
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fragility of Highway Embankments Exposed to Permanent Deformations Due to Underlying Fault Rupture

Geosciences
Seismic risk expresses the expected degree of damage and loss following a catastrophic event. An efficient tool for assessing the seismic risk of embankments is fragility curves.
Eleni Petala, Nikolaos Klimis
doaj   +1 more source

A new methodology of the development of seismic fragility curves

, 2014
There are continuous efforts to mitigate structural losses from earthquakes and manage risk through seismic risk assessment; seismic fragility curves are widely accepted as an essential tool of such efforts.
Lee, Young Joo, Moon, Dosoo
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Fragility Curves Derivation for a Pile-Supported Wharf

International Journal of Maritime Technology, 2013
This study aims to develop seismic fragility curves for a typical pile-supported wharf. Fragility curve is one of the popular tools in seismic performance evaluation of a structure.
Hamid Heidary Torkamani, Khosrow Bargi, Rouhollah Amirabadi   +2 more
doaj  

Fragility curves for tsunami loading

, 2015
Vulnerability to structural damage can be characterized by a fragility curve, which is expressed as the conditional probability of reaching or exceeding a particular damage state, expressed by a lognormal cumulative probability distribution, given a ...
Dias, WPS, Nanayakkara, KIU
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Study on the Uncertainty of Input Variables in Seismic Fragility Curves Based on the Number of Ground Motions

Applied Sciences
Seismic fragility curves, derived from ground motion data, are essential tools for predicting and assessing potential damage to structures during earthquakes.
Sangki Park, Dongwoo Seo, Kyusan Jung, Jaehwan Kim   +3 more
doaj   +1 more source