Results 41 to 50 of about 685,305 (257)
Yantu gongcheng xuebaoTo avoid the epistemic uncertainty for seismic fragility of subway station structures caused by the incomplete seismic demand sample set, a novel procedure of seismic fragility analysis of subway station structures considering the statistical uncertainty
CUI Chunyi 1 , XU Minze 1, XU Chengshun 2, ZHAO Jingtong 1, LIU Hailong 1, MENG Kun 3
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Seismic Risk Evaluation by Fragility Curves using Metamodel Methods [PDF]
, 2021 This study proposed an efficient and reliable fragility estimation by metamodel methods. To evaluate seismic risk, it is important to account for ground motions and structural parameter uncertainties.
Koh, C.G. +3 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Yantu gongcheng xuebao, 2022 Quantification of structural damage states in the fragility analysis and seismic performance evaluation of underground structures usually adopts the deterministic threshold values, which is a limitation in the framework of performance-based seismic ...
ZHONG Zi-lan , SHI Yue-bo , LI Jin-qiang , ZHAO Mi , DU Xiu-li
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
, 2015 Earthquakes continue to represent a serious threat for some European countries, particularly for Mediterranean bordering countries, where these events have been triggering significant destruction and loss over the last decades.
SIMOES DIAS MAIO Rui, TSIONIS Georgios
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Fragility, conflict, and migration
, 2023 Fragility, Conflict, and Migration addresses challenges to livelihood, food, and climate security faced by some of the most vulnerable populations worldwide.
Kosec, Katrina; Laderach, Peter; and Ruckstuhl, Sandra +1 more
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