Results 41 to 50 of about 54,055 (308)

Exploring the Effect of Near-Field Ground Motions on the Fragility Curves of Multi-Span Simply Supported Concrete Girder Bridges

Infrastructures
Investigating the impact of near-field ground motions on the fragility curves of multi-span simply supported concrete girder bridges is the main goal of this paper.
Hassan Soltanmohammadi, Mohammadreza Mashayekhi, Mohammad Mahdi Memarpour, Denise-Penelope N. Kontoni, Masoud Mirtaheri   +4 more
doaj   +1 more source

Seismic assessment of a multi-span steel railway bridge in Turkey based on nonlinear time history [PDF]

Natural Hazards and Earth System Sciences, 2018
Many research studies have shown that bridges are vulnerable to earthquakes, graphically confirmed by incidents such as the San Fernando (1971 USA), Northridge (1994 USA), Great Hanshin (1995 Japan), and Chi-Chi (1999 Taiwan) earthquakes, amongst many
M. F. Yılmaz, M. F. Yılmaz, B. Ö. Çağlayan   +2 more
doaj   +1 more source

Nonlinear dynamic analysis and seismic fragility assessment of a corrosion damaged integral bridge [PDF]

, 2016
Purpose In this paper the impact of corrosion of reinforcing steel in RC columns on the seismic performance of a multi-span concrete integral bridge is explored.
Alexander, Nicholas A, Crewe, Adam J, Kashani, Mohammad Mehdi, Lowes, Laura N, Ni Choine, Mairead, O' Conner, Alan, Padgett, Jamie E.   +6 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

First-order approximation towards empirical seismic vulnerability assessment of low-cost unreinforced masonry buildings in South Africa

Geomatics, Natural Hazards & Risk
The 5 August 2014 Orkney earthquake in South Africa caused significant damage to low-cost unreinforced masonry buildings. After the earthquake, post-earthquake surveys were conducted to assess damage and deduce the intensity experienced by these ...
Thando Nqasha, Zeenat Khoyratty, Mulemwa Akombelwa, Mayshree Singh, Andrzej Kijko   +4 more
doaj   +1 more source

Uncertainty and Quality rating in Analytical Vulnerability Assessment [PDF]

, 2014
Fragility curves represent a major component of seismic risk and vulnerability assessment of buildings and infrastructure facilities. A recently conducted extensive literature review under the framework of developing the “GEM Guide for Selecting of ...
D'Ayala, D, Ioannou, I, Lang, D, Meslem, A, Rossetto, T   +4 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Seismic fragility analysis of subway station structures considering statistical uncertainty of seismic demands

Yantu gongcheng xuebao
To avoid the epistemic uncertainty for seismic fragility of subway station structures caused by the incomplete seismic demand sample set, a novel procedure of seismic fragility analysis of subway station structures considering the statistical uncertainty
CUI Chunyi 1 , XU Minze 1, XU Chengshun 2, ZHAO Jingtong 1, LIU Hailong 1, MENG Kun 3
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Seismic performance assessment of subway station structures considering fuzzy probability of damage states

Yantu gongcheng xuebao, 2022
Quantification of structural damage states in the fragility analysis and seismic performance evaluation of underground structures usually adopts the deterministic threshold values, which is a limitation in the framework of performance-based seismic ...
ZHONG Zi-lan , SHI Yue-bo , LI Jin-qiang , ZHAO Mi , DU Xiu-li
doaj   +1 more source