Results 141 to 150 of about 92,560 (238)

Bibliometrics Analysis and Knowledge Mapping of Fragment-Based Drug Design Research: Trends from 2015 to 2024

Drug Design, Development and Therapy
Chenming He,1 Jirong Zhang,1 Runze Zhang,1 Liang Liu,1 Jielian Luo,1 Wen Zhang,1 Bangjiang Fang1,2 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Institute of Emergency and Critical Care ...
He C, Zhang J, Zhang R, Liu L, Luo J, Zhang W, Fang B   +6 more
doaj  

Fragment Based Drug Discovery by Microscale Thermophoresis Targeting <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> IspE. [PDF]

Drug Des Devel Ther
Walsh DJ, Willocx D, Hamid R, Hamed MM, Hirsch AKH.   +4 more
europepmc   +1 more source

C-H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD). [PDF]

Chem Sci, 2021
Chessari G, Grainger R, Holvey RS, Ludlow RF, Mortenson PN, Rees DC.   +5 more
europepmc   +1 more source

Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities

Advanced Materials, EarlyView.
This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen, Zhanxi Fan, Jingjie Ge, Qiyuan He, Zhuangchai Lai, Jiawei Liu, Chaoliang Tan, Hua Zhang   +7 more
wiley   +1 more source

Modular Synthetic Platform for the Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery. [PDF]

J Am Chem Soc
Gomez-Angel AR, Klein HF, Yao SY, Donald JR, Firth JD, Appiani R, Palmer CJ, Lincoln J, Lucas SCC, Fusani L, Storer RI, O'Brien P.   +11 more
europepmc   +1 more source

Fragment based drug discovery

Farumashia, 2012
TAKIMOTO–KAMIMURA, Midori, KUMAZAWA, Keiko   +1 more
openaire   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo. [PDF]

Nat Commun
Poole WG, Samways ML, Branduardi D, Taylor RD, Verdonk ML, Essex JW.   +5 more
europepmc   +1 more source

Is it time for biocatalysis in fragment-based drug discovery? [PDF]

Chem Sci, 2020
Ramsden JI, Cosgrove SC, Turner NJ.
europepmc   +1 more source