Results 151 to 160 of about 92,560 (238)

¹⁹F NMR viewed through two different lenses: ligand-observed and protein-observed ¹⁹F NMR applications for fragment-based drug discovery. [PDF]

RSC Chem Biol, 2021
Buchholz CR, Pomerantz WCK.
europepmc   +1 more source

True Closed‐Loop Recyclable Hydrogels Enabled by Imine Boronic Ester Crosslinking

Advanced Materials, EarlyView.
Subtle molecular differences in imine boronic ester crosslinkers profoundly influence hydrogel properties. 2‐formylphenylboronic acid crosslinkers form previously undisclosed 3‐amino‐benzoxaborole heterocycles, enhancing elasticity despite lower crosslinking density compared to their 4‐formylphenylboronic acid counterparts.
Jenna A. King, Joshua M. Litterio, Sean P. Larmore, Steven A. Lopez, Klaus Schmidt‐Rohr, Diego M. Alzate‐Sánchez   +5 more
wiley   +1 more source

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction. [PDF]

Angew Chem Int Ed Engl
Lin C, Narayanan D, Barreca M, Poulsen C, da Costa LS, Chen X, Wichman KG, Charley CA, Lindsay JL, Dezfouli M, Vlissari D, Mortensen TS, Chan CB, Wang J, Richardson W, Manning CE, Chen Z, Zang J, Käck H, Gajhede M, Bullock AN, Blake DJ, Olagnier D, Bach A.   +23 more
europepmc   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Data‐Driven Materials Science for Energy‐Sustainable Applications

Advanced Materials, EarlyView.
Data‐driven approaches powered by artificial intelligence are transforming materials discovery for energy sustainability. This review examines how auto‐generated high‐quality materials databases and domain‐specific language models accelerate research in photovoltaics, thermoelectrics, batteries and magnetic materials. Applications involve extraction of
Jacqueline M. Cole
wiley   +1 more source

Overcoming Clusterin-Induced Chemoresistance in Cancer: A Computational Study Using a Fragment-Based Drug Discovery Approach. [PDF]

Biology (Basel)
Caro EJGV, Gomez MC, Tsai PW, Tayo LL.
europepmc   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method. [PDF]

PLoS One
Chen W.
europepmc   +1 more source

Fragment-based drug discovery: opportunities for organic synthesis. [PDF]

RSC Med Chem, 2020
St Denis JD, Hall RJ, Murray CW, Heightman TD, Rees DC.   +4 more
europepmc   +1 more source

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source