Results 121 to 130 of about 1,379,022 (300)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer
, 2019 Apolipoprotein E is a 299-residue lipid carrier protein produced in both the liver and the brain. The protein has three major isoforms denoted apoE2, apoE3, and apoE4 which differ at positions 112 and 158 and which occur at different frequencies in the ...
Sanjay C. Panchal (3940073) +20 more
core +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
NMR methods for fragment selection
, 2014 International audienceFragment screening resides in the identification of minimal motifs responsible for the specific protein-ligand recognition. Once fragment hits have been identified, one needs to ensure that the fragments exhibit a specific binding ...
Krimm, Isabelle
core +3 more sources
Analysis of movement laws of fragment and shock wave from a blast fragmentation warhead
Journal of Measurement Science and Instrumentation, 2015 By studying shock wave propagation and fragment movement after the explosion of a blast fragmentation warhead,a whole calculation process about the place where fragments meet shock wave was proposed.A computing system for movement laws of fragments and ...
GONG Chao-an, CHEN Zhi-gang, YIN Li-kui
doaj
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Quêtes LittérairesCet article propose une lecture hypertextuelle du roman de Nadaud, Le Livre des malédictions, envisagé comme un palimpseste biblique : une réécriture fragmentaire, spéculative et profane de l’épisode mosaïque, qui donne une seconde vie narrative aux ...
Raja Mlayeh
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source