Results 111 to 120 of about 1,379,022 (300)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
CoRRWe survey systematic approaches to basis-restricted fragments of propositional logic and modal logics, with an emphasis on how expressive power and computational complexity depend on the allowed operators. The propositional case is well-established and serves as a conceptual template: Post's lattice organizes fragments via Boolean clones and supports ...
Nick Bezhanishvili +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
, 2019 Tuberculosis (TB) remains a leading cause of mortality amongst infectious diseases worldwide. InhA, an enoyl ACP-reductase, has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid.
Vitor Mendes (6702665) +9 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Fragment-based screening by protein crystallography: successes and pitfalls
, 2012 Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs.
Aaron Oakley (19584748) +2 more
core
Fragment-Based Identification of Influenza Endonuclease Inhibitors
, 2017 The influenza virus is responsible for millions of cases of severe illness annually. Yearly variance in the effectiveness of vaccination, coupled with emerging drug resistance, necessitates the development of new drugs to treat influenza infections.
Yao Chen (149006) +2 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Nordic Journal of Art and ResearchDette essayet handler om overflødige ting, det handler om skrift og det handler om å skrive en akademisk tekst. Den tyske filosofen Walter Benjamin (1892-1940) står sentralt for å belyse arbeidet.
Ingvard Bråten
doaj +1 more source
, 2011 Copyright information:Taken from "Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site"http://www.biomedcentral.com/1472-6807/7/72BMC Structural Biology 2007;7():72-72.Published online 6 Nov ...
Sheila Mulligan (84022) +5 more
core +1 more source