Results 101 to 110 of about 1,379,022 (300)
, 2018 Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5′-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine ...
Valerie Mizrahi (40126) +8 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Teksty Drugie, 2020 Mrowcewicz explores the voyeuristic element in The Manuscript Found in Saragossa by Count Jan Potocki, a book about peeping, tracking, investigating – a novel about windows, parted curtains, keyholes, mirrors; a tale of fragments, repetitions and ...
Krzysztof Mrowcewicz
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Kwartalnik Filmowy, 2000 Fragment powieści. Chociaż jeden z bohaterów nazywa się Edison, książka przesiąknięta jest atmosferą średniowiecznych opowieści o alchemikach i magach. Projekt Nowej Ewy powstaje w umyśle genialnego naukowca Edisona.
Auguste Villiers de L’Isle-Adam
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FRAGMENTATION AND HADRONIZATION [PDF]
International Journal of Modern Physics A, 2000 31 pages, 33 figures. Plenary talk at XIX International Symposium on Lepton and Photon Interactions at High Energies, Stanford, August ...
openaire +5 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Parse JournalThis is an experiment in fabulating while also thinking through what it might mean to fabulate, when the form is constitutive of the argument. It consists of nineteen fragments that appear in a random sequence each time they are read.[1] While fabulating
Emily Orley
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2016 Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-PLA2.
Vipulkumar K. Patel (2342794) +20 more
core +1 more source