Results 81 to 90 of about 1,379,022 (300)

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors

, 2018
Protein kinase C iota (PKC-ι) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of a fragment library has identified several hits from which an azaindole-based scaffold was chosen for optimization.
Eldwin Sum Wai Tan (1561678), Nur Huda Binte Ahmad (5175632), Nurul Dinie (5175638), Boping Liu (1589401), Anders Poulsen (809185), Thomas H. Keller (267928), Jacek Kwiatkowski (5175635), Guoying Chen (1487509), Sugunavathi Sepramaniam (258548), Shi Hua Ang (1550086), Joseph Cherian (619071), Zhi Ying Poh (2590708), Kanda Sangthongpitag (1550107), Alvin W. Hung (1980889), Soo Yei Ho (1550101), Esther HQ Ong (2590699), Jeffrey Hill (77412), May Ann Lee (649368), Doris Hui Ying Tee (5175629), Vishal Pendharkar (1550104), Yun Xuan Wong (2590705)   +20 more
core   +2 more sources

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Fetsund: Reimagining the Norwegian Village

Journal of Traditional Building, Architecture and Urbanism
Many towns in Norway are characterized by limited housing diversity and car-dependent residential areas. In contrast, several European cities are developing neighborhoods with dense but low-rise housing, based on participatory processes in which ...
Arild Eriksen, Kristoffer Røgeberg
doaj  

Fragment-Based Drug Design for Novel Inhibitors of Dengue Polymerase

This thesis explores the development of inhibitors for Dengue polymerase using fragment-based drug design. Fragment-based drug design often identifies very small molecules that bind weakly and require significant optimisation to develop them into higher ...
JAMIE HARPER CURRIE (17914676)
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Discovery of novel FGFR4 inhibitors through a build-up fragment strategy

Journal of Enzyme Inhibition and Medicinal Chemistry
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. FGFR4 has been implicated in HCC progression, making it a promising therapeutic target.
Jihyung Kim, Chang Gyun Im, Kyujin Oh, Ji Min Lee, Fatimah Al-Rubaye, Kyung Hoon Min   +5 more
doaj   +1 more source

Fragments, fragmentations

Calenda, 2019
Le topique du fragment est transversal à l’ensemble des sciences humaines et sociales. Il s’y décline diversement comme autant de modalités d’une incomplétude et souvent, par extension, d’une déficience. Les séances de ce séminaire viseront à identifier les potentialités du fragment en tant que tel pour l’investigation scientifique.
openaire   +1 more source

Fragmenting consciousness [PDF]

Proceedings of the National Academy of Sciences, 2012
The mechanism of human consciousness persists as a fundamental question in science and philosophy. As English biologist T. H. Huxley noted, “how it is that anything so remarkable as a state of consciousness comes about as the result of irritating nervous tissue, is just as unaccountable as the appearance of the Djin when Aladdin rubbed his lamp ...
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

L’Inconnu (1720) : une réactualisation paradoxale du ballet de cour

Bulletin du Centre de Recherche du Château de Versailles
As part of the great royal entertainments, celebrating the sovereign and the monarchy, court ballet reached its apogee under Louis XIV before declining: the comédie-ballet and the tragédie en musique ended up competing with court ballet while drawing on ...
Nathanaël Eskenazy
doaj   +1 more source