Results 91 to 100 of about 1,379,022 (300)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Crimes en trois lignes ou la possibilité d’un roman
América, 2013 Durant son exil mexicain, l’Espagnol Max Aub publie en 1956 un ensemble de textes brefs, Crímenes ejemplares, qui présentent à la première personne les causes et les modalités de divers crimes, absurdes, grotesques ou horribles. Le pourquoi et le comment
Marie Franco
doaj +1 more source
Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases
Fragment-based lead discovery has emerged over the last decades as one of the most powerful techniques for identifying starting chemical matter to target specific proteins or nucleic acids in vitro.
Sarah-Lisa Ouali (11608959) +15 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Fragment-based discovery and design of bacterial DsbA inhibitors
, 2017 Fragment-Based Drug Discovery (FBDD) is a relatively new approach to drug discovery that initially seeks to detect binding between potential drug targets and small compounds (fragments) having molecular weights between 150 and 300 Da.
Williams, Martin Lindesay (3754903)
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
ligand-discovery/fragment-predictor: Publication release
A small prediction app for fully functionalized ...
Miquel Duran-Frigola
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Exception Phrases as fragments: The case of Romanian [PDF]
Bucharest Working Papers in Linguistics, 2019 The paper proposes a formal account for Exception Phrases (EP) in Romanian. The analysis is expressed within the HPSG framework. We firstly show that an approach that treats EPs as structural ellipses faces multiple drawbacks.
Emil Ionescu
doaj