Results 61 to 70 of about 1,379,022 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Small models of convex fragments of definable subsets

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2020
This article discusses the problems of that part of Model Theory that studies the properties of countable models of inductive theories with additional properties, or, in other words, Jonsson theories.
A.R. Yeshkeyev, N.V. Popova
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

L’esthétique du fragment et l’identité chez Tahar Ben Jelloun et Fatou Diome [PDF]

open access: yesAnnales du Patrimoine, 2018
Le présent travail établit la corrélation entre l’esthétique du fragment et la crise identitaire du personnage postcolonial dans la prose romanesque de Tahar Ben Jelloun et celle de Fatou Diome.
Marcel Taibé
doaj  

Ludwig Tieck‘s Collection “Gedichte”: From a Fragment to an Encyclopedia [PDF]

open access: yesStudia Litterarum, 2018
The first poetic collection of Ludwig Tieck, Gedichte (Poems) came out in 1821, a few years after the publication of the six-volume Fantasus, a collection of all the most significant works of the author. Gedichte thus saw light during the period of Tieck’
Tatiana A. Zotova
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

La mÈre immigrÉe ou les fragments d’une mÉmoire brisÉe dans La DiscrÉtion de Faïza Guène [PDF]

open access: yesStudii si Cercetari Filologice: Seria Limbi Romanice
Cet article s’intéresse à l’étude des représentations de la figure maternelle dans le contexte migratoire, à travers une lecture postcoloniale du roman La Discrétion de l’écrivaine franco-algérienne Faïza Guène.
Bouchra EDDAHBI
doaj  

Eva Kmentová a tělesný otisk v umění šedesátých a sedmdesátých let

open access: yesActa Universitatis Carolinae Philosophica et Historica, 2017
This work deals with a physical body imprint in Art of sixties and seventies, analysing – in a form of comparative and case studies – selected works of the Czech sculptor Eva Kmentová (1928–1980).
Tereza Hrušková
doaj   +1 more source

Fragmentation and Integration [PDF]

open access: yes, 2021
Abstract This chapter is a response to the previous three chapters, in which it is argued that the relative weight of the Roman Empire was different between the West and the Abbasid caliphate, meaning that the categories of Sameness and Otherness that developed in the wake of the rise of Christendom in the West are not readily applicable
openaire   +2 more sources

ligand-discovery/fragment-embedding: Publication release

open access: yes
Create a fragment descriptor focused on the CRF fragment ...
Miquel Duran-Frigola
core   +1 more source

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