Results 141 to 150 of about 4,409,486 (250)

Self‐Healing Pd(II) Cage Metallogels for Iodine Capture in Water and Heterogeneous Photocatalysis

Advanced Science, EarlyView.
Two carbazole‐derived metal‐organic cages hierarchically self‐assemble into supramolecular metallogels that integrate autonomous self‐healing, reversible stimuli responsiveness, high‐capacity aqueous iodine capture, and visible‐light‐driven photocatalytic sulfide oxidation within a single multifunctional platform.
Monotosh Dalapati, Raghunath Singha, Debashree Manna, Dipak Samanta   +3 more
wiley   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Depemokimab: toward biannual biologic therapy for severe eosinophilic asthma. [PDF]

Respir Res
Papavassiliou KA, Gogou VA, Papavassiliou AG.   +2 more
europepmc   +1 more source

Phosphor‐Sensitized Ternary Organic Solar Cells Achieving 18.6% PCE via Ir(III)‐Mediated Triplet Energy Transfer and Non‐Radiative Recombination Suppression

Advanced Science, EarlyView.
A synergistic phosphor‐sensitization strategy (PSS) significantly enhances ternary OSCs performance. By integrating an Ir‐3 complex as a triplet energy mediator within a pyrazine‐based (N2) ternary blend (PM6:N2: L8‐BO) doped with 1 wt.% of Ir‐3 complex, and a PCE of 18.6% is achieved through efficient triplet‐triplet energy transfer (TTET), suppressed
Priyanka Yadav, Guohong Liu, Hyerin Kim, Songhyun Kim, Minsung Kim, Yeongbin Ma, Jisan Lim, Young Yong Kim, Taehyung Jang, Raja Kumaresan, Jinhwan Yoon, Sung‐Ho Jin   +11 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Why a positive rheumatoid factor test does not always mean rheumatoid arthritis. [PDF]

J Clin Invest
Van Kaer L.
europepmc   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Peripheral and Central Administration of Soluble Glycoprotein 130 Improves Cognitive Outcomes Following Controlled Cortical Impact in Male Mice. [PDF]

Neurotrauma Rep
Russell AL, Patel VS, Gober IG, Nasser L, Shah MK, Vadalia CN, Kline KE, Parthasarathy M, Vagni VA, Scott JA, Henry DJ, Carlson JC, Kochanek PM, Wagner AK.   +13 more
europepmc   +1 more source