Results 261 to 270 of about 121,391 (276)

Efficient inhibition of SARS-CoV-2 strains by a novel ACE2-IgG4-Fc fusion protein with a stabilized hinge region

bioRxiv, 2020
The novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) enters its host cells after binding to the angiotensin-converting enzyme 2 (ACE2) via its spike glycoprotein.
Hristo L. Svilenov, Julia Sacherl, A. Reiter, Lisa S. Wolff, Chongguang Chen, Marcel Stern, F. Wachs, Nicole Simonavicius, S. Pippig, F. Wolschin, J. Buchner, C. Brockmeyer, U. Protzer   +12 more
semanticscholar   +1 more source

Cellular effects and orientation of immobilized immunoglobulin are correlated to the charge-mediated influence of the antibody variable region.

Biointerphases
Ligand binding to a cell receptor often insufficiently triggers cellular immune responses. Receptor clustering through cross-linking occurs when a ligand binds to two or more receptors, amplifying cellular responses.
Hsi-Ju Wei, Jun Zhang, J. Barbon, Nancy Crosbie, Eric Dominguez   +4 more
semanticscholar   +1 more source

Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives

Clinical Microbiology Reviews
SUMMARY The human immunodeficiency virus (HIV) epidemic remains a formidable global health concern, with 39 million people living with the virus and 1.3 million new infections reported in 2022.
S. Mahomed
semanticscholar   +1 more source

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy

Science Advances
Interleukin-2 (IL-2) is a cytokine vital for CD8+ T cell activation and proliferation, holding great potential for cancer immunotherapy. Nevertheless, inherent shortcomings of short half-life, activation of regulatory T (Treg) cells, and systemic ...
Kai Yang, Bing Bai, Xiaomei Li, Wei Rou, Cheng Huang, Meixin Lu, Xueyan Zhang, Chunbo Dong, Shaolong Qi, Zhida Liu, Guocan Yu   +10 more
semanticscholar   +1 more source

Architecture of the high-affinity immunoglobulin E receptor.

Science Signaling
The high-affinity immunoglobulin E (IgE) receptor (FcεRI) drives type I hypersensitivity in response to allergen-specific IgE. FcεRI is a multimeric complex typically composed of one α, one β, and two disulfide-linked γ subunits.
Zhikuan Zhang, Moeko Yui, U. Ohto, Toshiyuki Shimizu   +3 more
semanticscholar   +1 more source

Antibody‐mediated control mechanisms of viral infections

Immunological Reviews
Antibodies generated after vaccination or natural pathogen exposure are essential mediators of protection against many infections. Most studies with viruses have focused on antibody neutralization, in which protection is conferred by the fragment antigen
Samatha R Mackin, Alan Sariol, Michael S. Diamond   +2 more
semanticscholar   +1 more source

#2042 Efficacy and safety of telitacicept in IgA nephropathy: a retrospective study

Nephrology, Dialysis and Transplantation
Telitacicept is a novel fusion protein composed of a recombinant transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor fused with the fragment crystallizable (Fc) region of human immunoglobulin G (IgG ...
Yuting Pan, Miao Yan, Huiming Wang, Cheng Chen   +3 more
semanticscholar   +1 more source

A Comprehensive Review on the Pharmacokinetics and Drug−Drug Interactions of Approved GLP-1 Receptor Agonists and a Dual GLP-1/GIP Receptor Agonist

Drug Design, Development and Therapy
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are peptide-derived analogs that were initially investigated to treat type 2 diabetes. Recently, a drug targeting the receptors of both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP ...
Jee Sun Min, Seongjun Jo, Sangyoung Lee, Duk Yeon Kim, Da Hyun Kim, Chae Bin Lee, Soo Kyung Bae   +6 more
semanticscholar   +1 more source

Expression, purification, crystallization of fragments from the C-terminal region of DFF45/ICAD

, 2003
Haitao Ding, Shihong Qiu, Songlin Li, J. Symerský, Todd J. Green, Ming Luo   +5 more
openalex   +1 more source

The crystallizable human myeloma protein Dob has a hinge-region deletion.

, 1979
Steiner La, Lopes Ad
semanticscholar   +1 more source