Results 21 to 30 of about 251,372 (253)

"Chciwiec na wydawnictwa z zakresu przyrodoznawstwa”. Lwowski nauczyciel Jan Smetański i fragment jego kolekcji w Bibliotece Śląskiej w Katowicach

Z Badań nad Książką i Księgozbiorami Historycznymi, 2020
Jan Smetanski (1881-1959), a Lviv natural historian and a high school teacher, was an avid bibliophile. He assembled a rich collection of 40,000 volumes, which was removed from Lviv after the war and located first in Przemysl and then in Katowice.
Weronika Pawłowicz
doaj   +1 more source

Production of a Human Recombinant Polyclonal Fab Antivenom against Iranian Viper Echis carinatus [PDF]

Archives of Razi Institute, 2018
Venomous snakebite is a life-threatening injury in many tropical and subtropical areas including Iran. The gold standard treatment option for human envenomation is the use of antivenoms.
M. H. Motedayen, G. Nikbakht Brujeni, M. J. Rasaee, A. Zare Mirakabadi, A. Khorasani, H. Eizadi, M. M. Ranjbar, S.M. Azimi, M. Esmaelizad   +8 more
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Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene^TM)

Molecules, 2023
Biomass-derived molecules can provide a basis for sustainable drug discovery. However, their full exploration is hampered by the dominance of millions of old-fashioned screening compounds in classical high-throughput screening (HTS) libraries frequently ...
Tom Dekker, Jaap W. Harteveld, Gábor Wágner, Max C. M. de Vries, Hans Custers, Andrea C. van de Stolpe, Iwan J. P. de Esch, Maikel Wijtmans   +7 more
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Detection and Evaluation of Non-Recombinants in cDNA Libraries by Multiple Cloning Region PCR

BioTechniques, 2002
Bacteriophages that are routinely used in cDNA libraries do not require any biological selection for forming plaques. Thus parental non-recombinant phages are always found in variable proportions together with recombinant ones in all cDNA libraries.
Dilip Bandyopadhyay, Farhad D. Vesuna
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A New LXX Fragment Containing Job 7:3-4 and 7:9

Tyndale Bulletin, 2015
This article presents an edition of a papyrus fragment from LXX Job that is housed in the Hatcher Graduate Library at the University of Michigan. The fragment likely dates to the sixth century A.D.AD and comes from a codex.
Lincoln H. Blumell
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Generation of a phagemid mouse recombinant antibody fragment library by multisite-directed mutagenesis

BioTechniques, 2003
A nonimmune phagemid recombinant antibody fragment (rFab) library was generated with a nominal diversity of 1.16 × 107 using the QuikChange® Multi Site-Directed Mutagenesis kit. Two degenerate primers spanning the third complementarity-determining region
Laura-Lee Clancy Kelley, Cory Momany
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HiFrAMes: A Framework for Hierarchical Fragmentation and Abstraction of Molecular Graphs

AI
Recent advances in computational chemistry, machine learning, and large-scale virtual screening have rapidly expanded the accessible chemical space, increasing the need for interpretable molecular representations that capture the hierarchical topological
Yuncheng Yu, Max A. Smith, Haidong Wang, Jyh-Charn Liu   +3 more
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Design, synthesis, and screening of an RNA optimized fluorinated fragment library

SLAS Discovery
Fragment-based screening is an efficient method for early-stage drug discovery. In this study, we aimed to create a fragment library optimized for producing high hit rates against RNA targets. RNA has historically been an underexplored target, but recent
Kasper P. Lundquist, Isabella Romeo, Raffaele B. Puglielli, Maëlle Pestalozzi, Marie L. Gram, Emily S. Hudson, Ofri Levi, Yoav S. Arava, Charlotte H. Gotfredsen, Mads H. Clausen   +9 more
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Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In various malaria-endemic regions, the appearance of resistance has precluded the use of pyrimidine-based antifolate drugs. Here, a three-step fragment screening was used to identify new non-pyrimidine Plasmodium falciparum dihydrofolate reductase ...
Marie Hoarau, Jarunee Vanichtanankul, Nitipol Srimongkolpithak, Danoo Vitsupakorn, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan   +5 more
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Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source