Results 121 to 130 of about 292,602 (339)
Advanced Science, EarlyView.Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo +6 more
wiley +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
The biology of frailty in humans and animals: Understanding frailty and promoting translation
Aging Medicine, 2019 Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to explain the heterogeneity in rates of aging in people of the same age.
Elise S. Bisset, Susan E. Howlett
doaj +1 more source
Aging, Frailty, and the Microbiome—How Dysbiosis Influences Human Aging and Disease
, 2020 John P. Haran, Beth A. McCormick
openalex +2 more sources
Advanced Science, EarlyView.In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo +6 more
wiley +1 more source
Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis
Advanced Science, EarlyView.Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang +7 more
wiley +1 more source
The Unintended Consequences of Flexicurity : The Health Consequences of Flexible Employment [PDF]
, 2015 Publisher ...
Bender, Keith Allen +1 more
core
Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics
Advanced Science, EarlyView.This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu +6 more
wiley +1 more source
Frailty and solid-organ transplant candidates: a scoping review [PDF]
, 2022 Jonathan Kao +9 more
openalex +1 more source