Results 151 to 160 of about 292,602 (339)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Reply Letter: A Commentary on “A Predictive Model of Failure to Rescue After Thoracolumbar Fusion” [PDF]

Neurospine
Joanna M. Roy, Aaron C. Segura, Michael M. Covell, Christian A. Bowers   +3 more
doaj   +1 more source

Consumers' Perspectives on the Design of a New Digital Frailty Education Course, ‘Focus on Frailty’: A Qualitative Co‐Design Study

Health Expectations
Introduction Frailty‐focused care in hospitals is hindered by systemic barriers, ageism and stereotypes about older adults and frailty. There is a need for frailty education to increase healthcare professionals' and students' understanding of frailty ...
Kristiana Ludlow, Benignus Logan, Jhalak Arora, Sarah Martin, Elizabeth Miller, Ruth E. Hubbard, Nicola Warren, Olivia Gallagher, Rosemary Saunders   +8 more
doaj   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Contribution of Lifestyle Habits, Geographic Location and Type of Work to the Manifestation of Individual Frailty Components in the Youngest-Old

, 2020
Véronique Provencher, François Béland, C. Galand, John Fletcher, Joël Tuakuila, Marie Pierre Garant   +5 more
openalex   +1 more source

Increasing Prevalence of Frailty and Its Association with Readmission and Mortality Among Hospitalized Patients with IBD

, 2021
Adam S. Faye, Timothy Wen, Ali Soroush, Ashwin N. Ananthakrishnan, Ryan C. Ungaro, Garrett Lawlor, Frank J. Attenello, William J. Mack, Jean‐Frédéric Colombel, Benjamin Lebwohl   +9 more
openalex   +2 more sources

Ultrathin, Unsinkable, Janus‐Faced Solar–Thermal Interfacial Evaporator for High‐Throughput Seawater Distillation and Solar‐Water Production

Advanced Science, EarlyView.
A nanostructured carbon‐coated porous polymeric scaffold is developed to accelerate the hydrological cycle, enabling solar–thermal freshwater production from saline water with reduced energy consumption and CO2 footprint. Abstract Solar–thermal distillation offers immense and hitherto untapped potential for energy‐efficient, sustainable freshwater ...
Mohammed Aslam Villan, Amrutha Suresh, Mukund Misra, Cintia Naranjo Ruiz, Neil R. Cameron, Sandip K. Saha, Subramaniam Chandramouli   +6 more
wiley   +1 more source

Frailty scale [PDF]

British Dental Journal, 2019
openaire   +2 more sources

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source