Results 171 to 180 of about 292,602 (339)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Ultrasound Controlled‐Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li, Mengxin Wang, Haonan Wang, Yang Sun, Yongyue Zhang, Shuyu Xu, Tianjiao Zhang, Shiti Shama, Xiaolong Liang, Shumin Wang   +9 more
wiley   +1 more source

Associations Between Growth Differentiating Factor-15 and Frailty in Older Adults From the MAPT Study. [PDF]

J Cachexia Sarcopenia Muscle
Sánchez-Sánchez JL, Rolland Y, Lucas A, Guyonnet S, Vellas B, de Souto Barreto P, MAPT/DSA Group.   +6 more
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance) [PDF]

Catherine Lai, Minji Lee, Olivia Bobek, Jennifer Le‐Rademacher, Sumithra J. Mandrekar, Gail J. Roboz, Geoffrey L. Uy, Jeanne S. Mandelblatt, Heidi D. Klepin   +8 more
openalex   +1 more source

Prevalence and Course of Frailty in Survivors of Critical Illness*

, 2020
Nathan E. Brummel, Timothy D. Girard, Pratik P. Pandharipande, Jennifer L. Thompson, Ryan T. Jarrett, Rameela Raman, Christopher G. Hughes, Mayur B. Patel, Alessandro Morandi, Thomas M. Gill, E. Wesley Ely   +10 more
openalex   +2 more sources

Frailty status but not age predicts complications in elderly cancer patients: a follow-up study [PDF]

, 2018
Marianne Ørum, Merete Gregersen, Kenneth Jensen, Peter Meldgaard, Else Marie Skjøde Damsgaard   +4 more
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Frailty and its impact on adverse outcomes in older patients with cancer in Vietnam [PDF]

Tan Van Nguyen, Quang Hiền Trần, Erkihun Tadesse Amsalu, Trinh Kim Thi Ngo, Thanh Dinh Le, Ying Zhang, Mark Woodward, Tu Ngoc Nguyen   +7 more
openalex   +1 more source