Results 181 to 190 of about 269,169 (284)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Low Body Mass Index Increases Frailty Risk in Old-Old Adults: Findings From a 3-Year Longitudinal Study. [PDF]

Geriatr Gerontol Int
Tabira K, Shiratsuchi D, Miyake Y, Makizako H.   +3 more
europepmc   +1 more source

Sulfide‐Based Electrolytes for All‐Solid‐State Sodium Batteries

Advanced Energy Materials, EarlyView.
This review covers the structural features and synthesis strategies of sulfide‐based solid electrolytes, as well as critical challenges related to conductivity, interfacial and moisture stability, and scaling‐up for practical application in Sodium‐based All Solid‐State Batteries.
Han Yang, Luca Weckelmann, Baolin Wu, Chih‐Long Tsai, Luc Raijmakers, Rüdiger‐A. Eichel, Anna Windmüller   +6 more
wiley   +1 more source

Older Adults, Anti-Amyloid Therapy, and Frailty: What Oncology Can Teach Us. [PDF]

Eur J Neurol
Borda MG, O'Hara-Veintimilla K, Aarsland D.   +2 more
europepmc   +1 more source

Early Outcomes After Total Arch Replacement With Frozen Elephant Trunk in Elderly Patients With Acute Type A Aortic Dissection

AGING MEDICINE, EarlyView.
Across seven centers (2015–2023), we studied 1634 ATAAD patients undergoing TAR+FET and, after propensity matching (n = 699), compared elderly (≥ 60) versus non‐elderly (< 60) outcomes. Elderly patients had higher 30‐day mortality and complications (log‐rank p = 0.002), supporting individualized hybrid strategies, organ‐protective perioperative care ...
Jiajun Liang, Yuan Xue, Yeting Lou, Hao Han, Xiaohan Zhong, Zhou Liu, Tianxu Han, Meili Wang, Wenjian Jiang, Hongjia Zhang, Haiyang Li, Yuanfei Zhao   +11 more
wiley   +1 more source

Frailty and Brain Myelin Across Adulthood: Multimodal MRI Insights From the BLSA. [PDF]

Aging Cell
Bouhrara M, Gong Z, Tanaka T, Ferrucci L.   +3 more
europepmc   +1 more source

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Impact of Preoperative Frailty on Postoperative Complications and Cognitive Impairment in Liver Cancer Patients: An Observational Cohort Study. [PDF]

Clin Interv Aging
Li Z, Yin T, Sun Y, Liu Z, Song S, Zhang X.   +5 more
europepmc   +1 more source

Predictive Model Development and Validation for Low Appendicular Skeletal Muscle Mass in Chinese Older Adults

AGING MEDICINE, EarlyView.
This predictive model divides the low ASMI into three risk categories. Older adults in the low‐risk category, for whom SMM measurement is probably unnecessary. ABSTRACT Objectives Low skeletal muscle mass is associated with adverse clinical outcomes. Due to constraints related to cost and equipment availability, direct measurement of skeletal muscle ...
Minmin Chen, Xiaoqing Wu, Yanping Du, Wenjing Tang, Weijia Yu, Huilin Li, Qun Cheng   +6 more
wiley   +1 more source

Temporal muscle thickness is associated with clinical frailty in patients with severe acute brain injury. [PDF]

JAR Life
Tam J, Tosh A, Coppler PJ, Faiver L, Case N, Callaway C, Elmer J.   +6 more
europepmc   +1 more source