Results 201 to 210 of about 180,045 (314)

Pre-frailty and frailty as independent predictors of mortality in U.S. breast cancer survivors: Evidence from the national health interview survey, 1997 to 2018: Frailty and all-cause mortality. [PDF]

Medicine (Baltimore)
Wu C, Du X, Li J, Yang X, Huang Y.
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

The Predictive Value of The 9-Point Clinical Frailty Scale on Outcomes in Older Adults with Hip Fracture: A Systematic Review. [PDF]

J Frailty Sarcopenia Falls
Goutsou S, Vasiliadis E, Kaspiris A, Goutsou K, Pneumaticos S.   +4 more
europepmc   +1 more source

Ageing and frailty

Hong Kong Medical Journal, 2022
openaire   +2 more sources

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Letter to the Editor: Physical frailty is the most important predictor of early mortality in hospitalized patients with decompensated cirrhosis. [PDF]

Hepatol Commun
Li CM, Feng X.
europepmc   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Comprehensive Geriatric Assessment in the Management of Frailty and Multimorbidity in Older Adults: A Systematic Literature Review. [PDF]

J Frailty Sarcopenia Falls
Roy S.
europepmc   +1 more source

Close relationships and risk of frailty: the Hertfordshire cohort study [PDF]

, 2012
Syddall, H.E., Brunner, Eric J, Sayer, A.A., Sayer, AA, Brunner, E.J., Gale, CR, Cooper, C., Bergman, H., Gale, Catharine R., Bergman, Howard, Bergman, H, Cooper, Cyrus, Cooper, C, Gale, C.R., Syddall, HE, Syddall, Holly E, Sayer, Avan Aihie, Brunner, EJ   +17 more
core   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source