Results 51 to 60 of about 264,721 (290)

Effects of Power-Oriented Resistance Training With Heavy vs. Light Loads on Muscle-Tendon Function in Older Adults: A Study Protocol for a Randomized Controlled Trial

Frontiers in Physiology, 2021
BackgroundPower-oriented resistance training (PRT) is one of the most effective exercise programs to counteract neuromuscular and physical function age-related declines.
Carlos Rodriguez-Lopez, Carlos Rodriguez-Lopez, Julian Alcazar, Julian Alcazar, Jose Losa-Reyna, Jose Losa-Reyna, Jose Losa-Reyna, Noelia Maria Martin-Espinosa, Ivan Baltasar-Fernandez, Ivan Baltasar-Fernandez, Ignacio Ara, Ignacio Ara, Robert Csapo, Luis M. Alegre, Luis M. Alegre   +14 more
doaj   +1 more source

The Effect of the Stretch-Shortening Cycle in the Force–Velocity Relationship and Its Association With Physical Function in Older Adults With COPD

Frontiers in Physiology, 2019
This study aimed to evaluate the effect of the stretch-shortening cycle (SSC) on different portions of the force–velocity (F–V) relationship in older adults with and without chronic obstructive pulmonary disease (COPD), and to assess its association with
Roberto Navarro-Cruz, Roberto Navarro-Cruz, Julian Alcazar, Julian Alcazar, Carlos Rodriguez-Lopez, Carlos Rodriguez-Lopez, Jose Losa-Reyna, Jose Losa-Reyna, Jose Losa-Reyna, Ana Alfaro-Acha, Ana Alfaro-Acha, Ignacio Ara, Ignacio Ara, Francisco J. García-García, Francisco J. García-García, Luis M. Alegre, Luis M. Alegre   +16 more
doaj   +1 more source

Urological-Geriatric Integrated Diagnostic-Therapeutic Pathway for elderly patients with urologic diseases

Geriatric Care, 2019
Aging of population represents a new challenge for physicians who have to deal with the balance of risk and benefit in a population that is poorly represented in clinical trials. Frail patients need individualized treatments because of their high risk of
Lisa Cammalleri, Romina Custureri, Monica Pomata, Fabio Bonini, Giacomo Capponi, Carlo Introini, Alberto Pilotto   +6 more
doaj   +1 more source

Adjuvant aromatase inhibitor treatment worsens depressive symptoms and sleep quality in postmenopausal women with localized breast cancer: A one-year follow-up study

Breast, 2022
First-line treatment in postmenopausal women with estrogen- and/or progesterone-positive breast cancer consists of aromatase inhibitors (AROi).
Javier García-Sánchez, Mayra Alejandra Mafla-España, María Dolores Torregrosa, Omar Cauli   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Androstenedione and Follicle-Stimulating Hormone Concentration Predict the Progression of Frailty Syndrome at One Year Follow-Up in Patients with Localized Breast Cancer Treated with Aromatase Inhibitors

Biomedicines, 2022
Background: The standard treatment in postmenopausal women with estrogen- and progesterone-positive localized breast cancer consists of aromatase inhibitors (AROi).
Javier García-Sánchez, Mayra Alejandra Mafla-España, María Dolores Torregrosa, Omar Cauli   +3 more
doaj   +1 more source

Beta-blockers and physical frailty in patients with end-stage liver disease. [PDF]

, 2018
AimTo investigate beta-blocker (BB) use in patients with cirrhosis and determine their effects on physical frailty and overall survival.MethodsAdult outpatients with cirrhosis listed for liver transplantation underwent testing of physical frailty using ...
Hayssen, Hilary, Kuo, Selena Z, Lai, Jennifer C, Lizaola, Blanca   +3 more
core  

Quality of life with conservative care compared with assisted peritoneal dialysis and haemodialysis [PDF]

, 2018
Background. There is little information about quality of life (QoL) for patients with end-stage kidney disease (ESKD) choosing conservative kidney management (CKM).
Barendse, Brown, Chandna, Da Silva-Gane, Davies, De Biase, Devins, Helvik, Hussain, Iyasere, Jakobsson, Jassal, Johansen, Kamar, Mahoney, Morton, Murphy, Murtagh, O'Connor, Okamoto, Rockwood, Roshanravan, Seow, Sexton, Shum, Verberne, Zigmond   +26 more
core   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source