Results 141 to 150 of about 25,104 (242)

Bridging Randomized Trial Efficacy and Real-World Effectiveness in Multiple Myeloma: Integrating Clinical Trials and Real-World Evidence for Individualized Care. [PDF]

Eur J Haematol
Martino EA, Vigna E, Bruzzese A, Amodio N, Caserta S, Lucia E, D'Arrigo G, Olivito V, Labanca C, Mendicino F, Alvaro ME, Tripepi G, Morabito F, Gentile M.   +13 more
europepmc   +1 more source

‘School is their whole world’: Teachers' perspectives on loneliness among children and adolescents from England and mainland China

British Educational Research Journal, EarlyView.
Abstract As front‐line observers and active participants in pupils' daily lives, teachers closely monitor pupils' social interactions, emotional states and behavioural changes. Their unique perspective enables them to detect problems in the social lives of their pupils that may not be immediately visible to peers, parents or mental health professionals.
Yixuan Zheng, Charlotte Bagnall, Caroline Bond, Elizabeth Birchinall, Pamela Qualter   +4 more
wiley   +1 more source

Individualizing Perioperative Analgesia: Patient-Specific Determinants of Postoperative Pain and Opioid-Related Outcomes. [PDF]

Medicina (Kaunas)
Kazemeini S, Shih R, Zhang S, Cohen R, LaBarre N, Ghani M, Tsao G.   +6 more
europepmc   +1 more source

Models for providing improved care in residential care homes: a thematic literature review [PDF]

This Annotated Bibliography is one output from a review of the available research evidence to support improved care in residential care homes as the needs of older people intensify. Key findings The review identified extremely little published evidence
Clay, Diane, Szczepura, Ala, Hyde, Julia, Wild, Deidre, Nelson, S. (Sara)   +4 more
core  

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Nutritional Status and Cardiovascular Disease in Older Adults: Clinical Perspectives from Mechanisms to Management. [PDF]

J Clin Med
Parrini I, Rao CM, Lucà F, Gulizia MM, Ceravolo R, Gelsomino S, Ingianni N, Ceruso CP, Iannì CS, Ferrò MT, Bilato C, Geraci G, Oliva F, Nardi F, Grimaldi M.   +14 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Critically Exploring Vulnerability in Frail Older Adults Following a Fall. [PDF]

Nurs Philos
Kitsiou M.
europepmc   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

A Qualitative Study on Self-Perceived Burden in Elderly Patients with Diabetes and Frailty Based on Social Ecological Theory. [PDF]

Patient Prefer Adherence
Chen M, Shi X, Tan J, Wang M, Pan X, Chen XL.   +5 more
europepmc   +1 more source