Results 181 to 190 of about 58,166 (260)

Continuous outcome estimation in N‐of‐1 trials for accelerated decision‐making

Epilepsia, EarlyView.
Abstract Objective N‐of‐1 trials aim to determine the therapeutic effect for a single individual. This individualized approach necessitates collecting multiple data points over time through repeated alternating periods of active treatment and a comparator or control condition.
Victoria Defelippe, František Bartoš, Eric‐Jan Wagenmakers, Kees P. J. Braun, Floor E. Jansen, Willem M. Otte   +5 more
wiley   +1 more source

Effects of nutritional guidance on frailty in older adults: A systematic review. [PDF]

J Nutr Health Aging
Koyama T, Nohara J, Nakamura M.
europepmc   +1 more source

Serum NfL, GFAP, and p‐tau217 in adults with drug‐resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury

Epilepsia, EarlyView.
Abstract Objective Adults with epilepsy and intellectual disabilities (IDs) may be at increased risk of dementia, but clinical evaluation is complex and use of conventional biomarkers is often considered too invasive. We explored abnormality of serum neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau‐217 (p ...
Hadassa Kwetsie, Inge M. W. Verberk, Jans S. van Ool, Anneke J. J. Rampen, Rebecca Z. Rousset, Nicole I. Wolf, Dederieke A. M. Maes‐Festen, Clara D. M. van Karnebeek, Charlotte E. Teunissen, Erik Boot, Agnies M. van Eeghen   +10 more
wiley   +1 more source

Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms. [PDF]

Medicine (Baltimore)
Kang YL, Kong JT, Tian H.
europepmc   +1 more source

Social participation and heat-related behavior in older adults during heat waves and on other days [PDF]

, 2018
A Makhelouf, A Stotz, AD Flouris, AG Barnett, BM Popkin, DD Pascoe, DL Groll, HS Jang, International Organization for Standardization, J Klenk, J Klenk, J Maas, J Tan, JA Loenhout Van, JA Wardekker, JL White-Newsome, JM Guralnik, K Burkart, KJ Collins, KL Bassil, Landeshauptstadt Stuttgart, Amt für Umweltschutz, Abt. Stadtklimatologie, LD Gillespie, LP Fried, M Power, PJ Clarke, R Kaiser, R Katzman, RG Steadman, T Liu, WL Kenney, Y Schoon   +30 more
core   +2 more sources

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Healthcare needs and priorities of older people living with heart failure and frailty: a multi-perspective study of patients, carers and clinicians. [PDF]

BMC Geriatr
Krishnan S, Gogoi M, Tarrant C, Conroy S, Clayton L, Squire IB, Sze S.   +6 more
europepmc   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Effectiveness on Frailty of an eHealth-Based Rehabilitation Program in Older People with Acute Heart Failure and/or Acute Coronary Syndrome: Study Protocol for a Randomized Trial and Baseline Data of Participants. [PDF]

J Clin Med
Cattadori G, Pedretti RFE, Sarzi Braga S, Maglio GM, Mancino M, Staine T, Mondaini S, Eramo L, Pellegrini V, La Grotta R, Bruno D, Patuzzo E, Matacchione G, Giuliani A, Carbonara R, Ferrulli A, Venneri M, Osella C, Quarto L, Genco M, D'Addabbo I, Camicia F, Palazzo L, Caruso A, Spazzafumo L, Olivieri F, Tagliabue E, Prattichizzo F, Passantino A.   +28 more
europepmc   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source