Results 191 to 200 of about 22,611 (245)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Prevalence and Outcomes of Frailty in Older Men-the Manitoba Follow-Up Study. [PDF]

Can Geriatr J
St John PD, Tate RB.
europepmc   +1 more source

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, EarlyView.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Early Risk Stratification and Mortality Prediction in Gastrointestinal Perforation: A Retrospective Cohort Study for Personalized Surgical Decision Making. [PDF]

J Pers Med
Colombo G, Longhi M, Capuzzo M, Bisagni P.   +3 more
europepmc   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Housing Insecurity, Incident Geriatric Conditions, and Mortality in Community-Living Older Persons.

JAMA Netw Open
Wang Y, Davis-Plourde K, Vander Wyk B, Paredes LG, Gill TM, Becher RD.   +5 more
europepmc   +1 more source

The impact of integrated care on quality of life in community-dwelling older adults with frailty: A systematic review and mixed method synthesis. [PDF]

J Frailty Aging
Boyce J, Patton D, Watson C, O'Connor T, Moore Z, Nugent L.   +5 more
europepmc   +1 more source

Uneven Impacts of Seawall Heightening on Tsunami Risk Reduction under Rising Sea Levels: Probabilistic Scenarios from the Japan Trench

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Disasters exacerbated by climate change have prompted adaptation measures, including seawall heightening, which is an effective approach to protecting coastal areas. However, the combined effect of rising sea levels and tsunamis can create a compound coastal hazard, in which long‐term sea level rise amplifies the impact of tsunamis.
Yushi Miki, Anawat Suppasri, Constance Ting Chua, An‐Chi Cheng, Tomoya Iwasaki, Yugo Shinozuka, Takafumi Ogawa, Fumihiko Imamura   +7 more
wiley   +1 more source

Influencing factors of oral frailty in Chinese maintenance hemodialysis patients: a Bayesian network analysis. [PDF]

Ren Fail
Fang Y, Jiang Q, Zeng R, Gan X, Wei P, Du J, Lin X, Yang Q.   +7 more
europepmc   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source