Results 191 to 200 of about 394,012 (302)

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity. [PDF]

J Virol
Wang Y, Fu S, Wang X, Gao G.
europepmc   +1 more source

Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly [PDF]

, 2017
Albracht, Derek, et al,, Fulton, Robert S, Graves-Lindsay, Tina, Kremitzki, Milinn, Magrini, Vincent, Markovic, Chris, McGrath, Sean, Steinberg, Karyn Meltz, Wilson, Richard K   +9 more
core   +2 more sources

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

Yeast, EarlyView.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias, Fernanda Pinheiro Moreira Freitas, Eduardo Luís Menezes de Almeida, Luciano Gomes Fietto, Agustin Zsögön, Wendel Batista da Silveira   +5 more
wiley   +1 more source

Conformational Analysis and Structure-Altering Mutations of the HIV-1 Frameshifting Element. [PDF]

Int J Mol Sci
Newton K, Yan S, Schlick T.
europepmc   +1 more source

Multilocus sequence typing of the invasive pest Halyomorpha halys (Hemiptera: Pentatomidae) and associated endosymbiont reveals unexplored diversity

Insect Science, EarlyView.
A multilocus sequence typing approach is proposed to explore Halymorpha halys genetic diversity, taking into consideration both insect nuclear markers and markers from the gut symbiont “Candidatus Pantoa carbekii.” Increased information was revealed regarding the number of distinct holobiont haplotypes in native and invasive populations of the pest ...
Matteo Dho, Matteo Montagna, Chenxi Liu, Giulia Magoga, Giobbe Forni, Alberto Alma, Elena Gonella   +6 more
wiley   +1 more source

Surface Plasmon Resonance Analysis for Evaluating ASO Targeting Structured RNA. [PDF]

Methods Protoc
Shinozaki T, Hasegawa T, Akter MT, Kumagai K, Suzuki Y, Sakamoto T.   +5 more
europepmc   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants [PDF]

, 2017
Altschul, Blanchard, Bonnefond, Clark, Clark, Cline, Dalkilic, David N Cooper, de Ligt, De Rubeis, Denis, Depienne, Dinkel, Douville, Elkan, Epi4K Consortium and Epilepsy Phenome/Genome Project, EuroEPINOMICS-RES Consortium, Epilepsy Phenome/Genome Project and Epi4K Consortium, Folkman, Fromer, Gilissen, Girard, Guan Ning Lin, Guipponi, Gulsuner, Hashimoto, Hsiao, Hu, Hyun-Jun Nam, Iossifov, Iossifov, Jain, Jain, Jiang, Jonathan Sebat, Karolchik, Kircher, Kong, Kymberleigh A Pagel, Landrum, Lek, Li, Lilia M Iakoucheva, MacArthur, MacArthur, Maquat, Matthew Mort, McCarthy, Menon, Mort, Mushegian, Neale, Ng, O’Roak, O’Roak, O’Roak, Pei, Pejaver, Peng, Predrag Radivojac, Radivojac, Radivojac, Ramachandrappa, Rauch, Rausell, Riedmiller, Risso, Ronemus, Rost, Sanders, Sean D Mooney, Sigrist, Stenson, Sulem, Suzek, Thousand Genomes Project Consortium, Turner, Vikas Pejaver, Xu, Xu, Yuen, Yuen, Zia   +81 more
core   +2 more sources

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source