Results 1 to 10 of about 617,976 (302)

Translational Regulation of Utrophin by miRNAs [PDF]

PLoS ONE, 2011
Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne Muscular Dystrophy (DMD) locus. Its regulation is of therapeutic interest as its overexpression can compensate for dystrophin's absence in animal models of DMD. The tissue distribution and transcriptional regulation of utrophin have been characterized extensively, and more ...
Utpal Basu, Olga Lozynska, Catherine Moorwood, Gopal Patel, Steve D Wilton, Tejvir S Khurana   +5 more
openaire   +5 more sources

Translational Regulation of TRAIL Sensitivity [PDF]

Cell Cycle, 2005
TNF-related apoptosis-inducing ligand (TRAIL) is a peptide that induces apoptosis to varying degrees in tumor cells. While TRAIL sensitivity in tumors has been linked to c-myc- and MEK/Erk-induced enhancement of caspase activation, our recent study identified a third input controlling TRAIL sensitivity, namely the Akt-mTOR pathway.
Amith, Panner, Andrew T, Parsa, Russell O, Pieper   +2 more
openaire   +2 more sources

ShennongAlpha: an AI-driven sharing and collaboration platform for intelligent curation, acquisition, and translation of natural medicinal material knowledge

Cell Discovery
Natural Medicinal Materials (NMMs) have a long history of global clinical applications and a wealth of records and knowledge. Although NMMs are a major source for drug discovery and clinical application, the utilization and sharing of NMM knowledge face ...
Zijie Yang, Yongjing Yin, Chaojun Kong, Tiange Chi, Wufan Tao, Yue Zhang, Tian Xu   +6 more
doaj   +1 more source

Emerging Roles and Landscape of Translating mRNAs in Plants

Frontiers in Plant Science, 2017
Plants use a wide range of mechanisms to adapt to different environmental stresses. One of the earliest responses displayed under stress is rapid alterations in stress responsive gene expression that has been extensively analyzed through expression ...
Gaurav Sablok, Gaurav Sablok, Jonathan J. Powell, Kemal Kazan, Kemal Kazan   +4 more
doaj   +1 more source

β-Catenin: A Metazoan Filter for Biological Noise?

Frontiers in Genetics, 2019
Molecular noise refers to fluctuations of biological signals that facilitate phenotypic heterogeneity in a population. While endogenous mechanisms exist to limit genetic noise in biological systems, such restrictions are sometimes removed to propel ...
Saba Rezaei-Lotfi, Saba Rezaei-Lotfi, Neil Hunter, Neil Hunter, Ramin M. Farahani, Ramin M. Farahani   +5 more
doaj   +1 more source

Human eRF1 Translation Regulation

Molecular Biology
Abstract Eukaryotic translation release factor eRF1 is an important cellular protein that plays a key role in translation termination, nonsense-mediated mRNA decay (NMD), and readthrough of stop codons. The amount of eRF1 in the cell influences all these processes. The mechanism of regulation of eRF1 translation
A V, Shuvalov, A A, Klishin, N S, Biziaev, E Y, Shuvalova, E Z, Alkalaeva   +4 more
openaire   +2 more sources

Protein Kinases at the Intersection of Translation and Virulence

Frontiers in Cellular and Infection Microbiology, 2019
As free living organisms, fungi are challenged with a variety of environmental insults that threaten their cellular processes. In some cases, these challenges mimic conditions present within mammals, resulting in the accidental selection of virulence ...
Jay Leipheimer, Amanda L. M. Bloom, John C. Panepinto   +2 more
doaj   +1 more source

Targeting YBX1‐m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma

Clinical and Translational Medicine
Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation of ferroptosis is closely associated with HCC. However, the effect of the epigenetic mRNA m5C modification on ferroptosis in
Ouwen Li, Ke An, Han Wang, Xianbin Li, Yueqin Wang, Lan Huang, Yue Du, Nuo Qin, Jiasheng Dong, Jingyao Wei, Ranran Sun, Yong Shi, Yanjia Guo, Xiangyi Sun, Ying Yang, Yun‐Gui Yang, Quancheng Kan, Xin Tian   +17 more
doaj   +1 more source

Translational machinery and translation regulation in axon regeneration

Neural Regeneration Research
International ...
Homaira Nawabi, Stephane Belin
openaire   +4 more sources

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Cells, 2019
In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as ...
Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield   +3 more
doaj   +1 more source