Preferential translation of p53 target genes
RNA Biology, 2022 The transcription factor p53 exerts its tumour suppressive effect through transcriptional activation of numerous target genes controlling cell cycle arrest, apoptosis, cellular senescence and DNA repair. In addition, there is evidence that p53 influences
Miharu Hisaoka +5 more
doaj +1 more source
Post-translational regulation enables robust p53 regulation [PDF]
, 2013 Background The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance ...
Brandon Hencey +9 more
core +3 more sources
Translating translation: Regulated protein translation as a biomedical intervention [PDF]
Fly, 2009 Altering the cellular response to internal and external stressors is essential for survival, hence the process of translation is exquisitely regulated to rapidly change the proteomic profile upon physiological challenges. We recently reported that genetic and pharmacological manipulation of translation may be beneficial in the treatment of Parkinson ...
Luke S, Tain, Alexander J, Whitworth
openaire +2 more sources
Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea : research article [PDF]
, 2007 Background Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist.
Schuster Stephan C +31 more
core +1 more source
Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions [PDF]
, 2021 The alveolates (Superphylum Alveolata) comprise a group of primarily single-celled eukaryotes that have adopted extremely diverse modes of nutrition, such as predation, photoautotrophy and parasitism.
Lange, S. +2 more
core +1 more source
A quantitative estimation of the global translational activity in logarithmically growing yeast cells. [PDF]
, 2008 BACKGROUND: Translation of messenger mRNAs makes significant contributions to the control of gene expression in all eukaryotes. Because translational control often involves fractional changes in translational activity, good quantitative descriptions of ...
von der Haar, Tobias +1 more
core +1 more source
Regulation of Translation and Cancer [PDF]
Cell Cycle, 2004 One of the effects of oncogenic signaling appears to be differentiated recruitment of mRNA's to ribosomes. The mRNA's so affected frequently encode proteins involved in growth regulation cell-cell interaction. These functions are critical for both cancer and development, potentially suggesting that the normal role of differential translation may be ...
openaire +2 more sources
Translational regulation in mycobacteria and its implications for pathogenicity [PDF]
, 2018 Protein synthesis is a fundamental requirement of all cells for survival and replication. To date, vast numbers of genetic and biochemical studies have been performed to address the mechanisms of translation and its regulation in Escherichia coli, but ...
Sawyer, E.B., Grabowska, A., Cortes, T.
core +1 more source
Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]
, 2008 Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G +12 more
core +1 more source
Translational regulation in pathogenic and beneficial plant-microbe interactions
, 2021 Plants are surrounded by a vast diversity of microorganisms. Limiting pathogenic microorganisms is crucial for plant survival. On the other hand, the interaction of plants with beneficial microorganisms promotes their growth or allows them to overcome ...
Ferrari, Milagros +3 more
core +1 more source