Results 41 to 50 of about 933,800 (312)
Kinetochore inactivation by expression of a repressive mRNA. [PDF]
, 2017 Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes.
Chen, Jingxun +8 more
core +2 more sources
Stem Cell Reports, 2023 Summary: Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels.
Marino Caruso +13 more
doaj +1 more source
The Epitranscriptome in Translation Regulation [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer +3 more
openaire +2 more sources
Protein-Based Systems for Translational Regulation of Synthetic mRNAs in Mammalian Cells
Life, 2021 Synthetic mRNAs, which are produced by in vitro transcription, have been recently attracting attention because they can express any transgenes without the risk of insertional mutagenesis.
Hideyuki Nakanishi
doaj +1 more source
Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]
, 2019 Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong +6 more
core +1 more source
Consolidation and translation regulation.
Learning & memory (Cold Spring Harbor, N.Y.), 2012 mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting ...
Gal-Ben-Ari, Shunit +14 more
openaire +3 more sources
Translational Regulation of Cytoplasmic mRNAs [PDF]
The Arabidopsis Book, 2013 Translation of the coding potential of a messenger RNA into a protein molecule is a fundamental process in all living cells and consumes a large fraction of metabolites and energy resources in growing cells. Moreover, translation has emerged as an important control point in the regulation of gene expression.
Roy, Bijoyita, von Arnim, Albrecht G.
openaire +3 more sources
Communications BiologyIschemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion.
Jinze Li +13 more
doaj +1 more source
Molecular Systems Biology, 2016 Transcription initiated at alternative sites can produce mRNA isoforms with different 5ʹUTRs, which are potentially subjected to differential translational regulation.
Xi Wang +3 more
doaj +1 more source
BMC Medicine, 2020 Background Little is known about the inter-relationship among fruit and vegetable intake, gut microbiota and metabolites, and type 2 diabetes (T2D) in human prospective cohort study.
Zengliang Jiang +17 more
doaj +1 more source