Results 61 to 70 of about 617,976 (302)

Consolidation and translation regulation.

Learning & memory (Cold Spring Harbor, N.Y.), 2012
mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting ...
Gal-Ben-Ari, Shunit, Kenney, Justin W., Ounalla-Saad, Hadile, Taha, Elham, David, Orit, Levitan, David, Gildish, Iness, Panja, Debabrata, Pai, Balagopal, Wibrand, Karin, Simpson, T. Ian, Proud, Christopher G., Bramham, Clive R., Armstrong, J. Douglas, Rosenblum, Kobi   +14 more
openaire   +3 more sources

A role of plakophilins in the regulation of translation [PDF]

Cell Cycle, 2010
Plakophilins 1-3 are members of the p120(ctn)-family of armadillo related proteins. They have been characterized as desmosomal plaque proteins, stabilizing desmosomal cadherins at the plasma membrane and interacting with the cytoskeletal linker protein desmoplakin. Loss of cell adhesion contributes to cancerogenesis. In agreement with this, some tumors
Annika, Wolf, Mechthild, Hatzfeld
openaire   +2 more sources

Circadian regulation of translation

RNA Biology
Most, if not all organisms exhibit robust rhythmicity of their biological functions, allowing a perpetual adaptation to external clues within the daily 24 hours-cycle. Studies on circadian rhythm regulation primarily focused on transcriptional level, considering mRNA levels to represent the primary determinant of oscillations of intracellular protein ...
Jiali Lyu, Yanrong Zhuang, Yi Lin
openaire   +3 more sources

Ca2+ oscillation in vascular smooth muscle cells control myogenic spontaneous vasomotion and counteract post-ischemic no-reflow

Communications Biology
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion.
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia   +13 more
doaj   +1 more source

Dietary fruit and vegetable intake, gut microbiota, and type 2 diabetes: results from two large human cohort studies

BMC Medicine, 2020
Background Little is known about the inter-relationship among fruit and vegetable intake, gut microbiota and metabolites, and type 2 diabetes (T2D) in human prospective cohort study.
Zengliang Jiang, Ting-yu Sun, Yan He, Wanglong Gou, Luo-shi-yuan Zuo, Yuanqing Fu, Zelei Miao, Menglei Shuai, Fengzhe Xu, Congmei Xiao, Yuhui Liang, Jiali Wang, Yisong Xu, Li-peng Jing, Wenhua Ling, Hongwei Zhou, Yu-ming Chen, Ju-Sheng Zheng   +17 more
doaj   +1 more source

Protein-Based Systems for Translational Regulation of Synthetic mRNAs in Mammalian Cells

Life, 2021
Synthetic mRNAs, which are produced by in vitro transcription, have been recently attracting attention because they can express any transgenes without the risk of insertional mutagenesis.
Hideyuki Nakanishi
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Regulating mRNA translation with a kiss [PDF]

Nucleic Acids Symposium Series, 2008
Loop-loop interactions mediate the recognition between RNA hairpins leading to the formation of so-called kissing complexes. Both the size and the sequence of the loop are critical for ensuring stable interaction. Using in vitro selection we have characterized a few loop sequences that lead to the formation of highly stable kissing complexes.
Eric, Dausse, Cédric, Belair, Cathy, Staedel, Jean-Jacques, Toulmé   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Post-translational regulation of CRMP in developing and regenerating chick spinal cord

, 2010
It is becoming apparent that regulation at the protein level plays crucial roles in developmental and pathological processes. Therefore, we performed a proteomics screen to identify proteins that are differently expressed or modified at stages of ...
Lange, S., Leung Kit-Y, Ferretti, P., Gogel, S., Greene, N.D.E.   +4 more
core   +1 more source