Results 21 to 30 of about 617,976 (302)

Microbiota-assisted iron uptake promotes immune tolerance in the intestine

Nature Communications, 2023
Iron deficiencies are the most common nonenteric syndromes observed in patients with inflammatory bowel disease, but little is known about their impacts on immune tolerance.
Lizhen Zhu, Geng Li, Zhixin Liang, Tuan Qi, Kui Deng, Jiancheng Yu, Yue Peng, Jusheng Zheng, Yan Song, Xing Chang   +9 more
doaj   +1 more source

The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA

Communications Biology, 2023
The antidiabetic drug, metformin, helps E. coli gather vitamin B12 from the environment by increasing the expressions of transporter genes in a RcdA-dependent manner.
Luxia Yao, Yihan Wang, Shenlu Qin, Shihao Zhu, Lianfeng Wu   +4 more
doaj   +1 more source

Proteins secreted by brain arteriolar smooth muscle cells are instructive for neural development

Molecular Brain, 2022
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development.
Xuzhao Li, Lili Zhou, Xiaoxuan Zhang, Yuxiao Jin, Bingrui Zhao, Dongdong Zhang, Chengjie Xi, Jiayu Ruan, Zhu Zhu, Jie-Min Jia   +9 more
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The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Nature Communications, 2022
Chronic insomnia is associated with cardiometabolic diseases. Here, in two clinical cohorts (n = 7,931), authors show that gut microbiota-bile acid axis may be an intervention target to attenuate the impact of chronic insomnia on cardiometabolic health.
Zengliang Jiang, Lai-bao Zhuo, Yan He, Yuanqing Fu, Luqi Shen, Fengzhe Xu, Wanglong Gou, Zelei Miao, Menglei Shuai, Yuhui Liang, Congmei Xiao, Xinxiu Liang, Yunyi Tian, Jiali Wang, Jun Tang, Kui Deng, Hongwei Zhou, Yu-ming Chen, Ju-Sheng Zheng   +18 more
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Translational Regulation in Nutrigenomics [PDF]

Advances in Nutrition, 2011
The emergence of genome-wide analysis to interrogate cellular DNA, RNA, and protein content has revolutionized the study of the control network that mediates cellular homeostasis. Nutrigenomics addresses the effect of nutrients on gene expression, which provides a basis for understanding the biological activity of dietary components.
Botao, Liu, Shu-Bing, Qian
openaire   +2 more sources

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

BMC Medicine, 2021
Background Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations.
Yuanqing Fu, Fengzhe Xu, Longda Jiang, Zelei Miao, Xinxiu Liang, Jian Yang, Susanna C. Larsson, Ju-Sheng Zheng   +7 more
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The Epitranscriptome in Translation Regulation [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer, Sharon, Moshitch-Moshkovitz, Gideon, Rechavi, Dan, Dominissini   +3 more
openaire   +2 more sources

Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response

BMC Immunology, 2020
Background Cancer cells subvert natural immunosuppression by upregulating the expression of checkpoint proteins and their ligands. For example, tumor cells expressing programmed death-ligand 1 (PD-L1) induce immune cell tolerance to cancers, thereby ...
Isabella McGoverne, Jenny Dunn, Jacob Batham, Wen Juan Tu, Jeremy Chrisp, Sudha Rao   +5 more
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Canonical and early lineage-specific stem cell types identified in planarian SirNeoblasts

Cell Regeneration, 2021
Background The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining cells with SiR-DNA and Cell ...
Kaimeng Niu, Hao Xu, Yuanyi Zhou Xiong, Yun Zhao, Chong Gao, Chris W. Seidel, Xue Pan, Yuqing Ying, Kai Lei   +8 more
doaj   +1 more source

Translation Initiation Factor eIF4E Positively Modulates Conidiogenesis, Appressorium Formation, Host Invasion and Stress Homeostasis in the Filamentous Fungi Magnaporthe oryzae

Frontiers in Plant Science, 2021
Translation initiation factor eIF4E generally mediates the recognition of the 5’cap structure of mRNA during the recruitment of the ribosomes to capped mRNA.
Wajjiha Batool, Wajjiha Batool, Ammarah Shabbir, Ammarah Shabbir, Lili Lin, Lili Lin, Xiaomin Chen, Xiaomin Chen, Qiuli An, Qiuli An, Xiongjie He, Xiongjie He, Shu Pan, Shu Pan, Shuzun Chen, Shuzun Chen, Qinghe Chen, Qinghe Chen, Qinghe Chen, Zonghua Wang, Zonghua Wang, Zonghua Wang, Justice Norvienyeku, Justice Norvienyeku, Justice Norvienyeku   +24 more
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