Results 71 to 80 of about 5,977,796 (339)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Architecture et interdisciplinarité. Le cas d’étude des instituts de la complexité

open access: yesNatures Sciences Sociétés, 2020
Un certain nombre d’historiens et de sociologues ont interrogé la relation entre socialisation et architecture. Mais rares sont les auteurs ayant réfléchi au lien entre architecture et production des savoirs scientifiques.
Li Vigni Fabrizio
doaj   +1 more source

The education and practice gap of accounting [PDF]

open access: yes, 2018
Educators nowadays may equip students for jobs that will not exist in the future (Shusterman, 2015) or jobs that do not exist yet. Many students face confession after graduating from tertiary education.
France, Adrian, Li, Angela
core  

Dueling for honor and identity economics [PDF]

open access: yes, 2012
Dueling is one of the best indicators of political transition from anarchy to order. This paper explores the dynamics of dueling for honor as a social institution in England, France, and Germany.
Hassani Mahmooei, Behrooz   +1 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Characterization of the first true coaxial 18-fold segmented n-type prototype detector for the GERDA project [PDF]

open access: yes, 2007
The first true coaxial 18-fold segmented n-type HPGe prototype detector produced by Canberra-France for the GERDA neutrinoless double beta-decay project was tested both at Canberra-France and at the Max-Planck-Institut fuer Physik in Munich.
A. Caldwell   +17 more
core   +2 more sources

France

open access: yes, 2023
France is known as a highly centralized country. In fact, the centralist approach applied to the field of urban planning after the Second World War until the end of the twentieth century. However, in 1982 and 1983, a set of decentralization laws changed the situation.
Guelton, Sonia, Verhage, Roelof
openaire   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

France

open access: yes, 2011
History of the french community of historian ...
Veronica Estay Stange, Denis Bertrand
openaire   +7 more sources

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