Results 61 to 70 of about 1,436,252 (268)
The EU is preparing for a geopolitical breakthrough [PDF]
Научно-аналитический вестник Института Европы РАН, 2019 The year 2019 turned out to be very dramatic and in many respects decisive for the EU policy for the near future. In December, it became completely clear that «Brexit should be» – albeit in the year 2020, that is, much later than the British supporters ...
Alexander Shumilin
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Intricacies of French engagement in Sahel with peace prospects
Social Development & SecurityThe Sahel region faces an extreme human security crisis with complex security challenges rooted in historical, ethnic, and geopolitical ties. Decades of armed violence and unstable socio-political systems have led to deteriorating security conditions ...
Shubhdayini Rajyalaxmi Jandev
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
REPORTING LAW IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT: FRENCH EXPERIENCE
Учёт. Анализ. Аудит, 2019 Humanity is getting more and more concerned with the environmental and social issues. In this regard, accounting for sustainable development should enable the companies and the general public to obtain information which is required for the effective ...
YULIA Altukhova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Comparing social representations of the landscape: a methodology
Ecology and Society, 2020 Social representations (SRs) are systems of values, ideas, and practices that characterize individuals' and social groups' relationships to both their social and natural environment.
Carole Vuillot +2 more
doaj +1 more source