Results 81 to 90 of about 1,436,252 (268)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The 2012 phenomenon in South-West France [PDF]

open access: yesStudia Ethnologica Pragensia, 2018
The 2012 phenomenon is discussed, especially its development in The Two Rennes and Bugarach Area in South-West France. First the ideas and beliefs of the “alternative seekers” and the growth of an expectation of spiritual renewal on 21st December 2012 ...
Véronique Campion-Vincent
doaj  

Obsidian Studies in the Prehistoric Central Mediterranean: After 50 Years, What Have We Learned and What Still Needs to Be Done?

open access: yesOpen Archaeology, 2017
Obsidian sourcing studies have been conducted in the central Mediterranean for more than 50 years. Detailed studies have been done on the geological sources on four Italian islands, and many analytical methods have been used to successfully distinguish ...
Tykot Robert H.
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

The giant of Montenegro: Jovo Poček: A volunteer of the Canadian army in World war I [PDF]

open access: yesBaština, 2017
Upon the outbreak of World War I, and the entry of Great Britain into this conflict, the British also sent the soldiers from their colonial estates to the western front battlefield, but also from other dominions from around the globe, whom the British ...
Damjanović Miloš M.
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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