Results 71 to 80 of about 1,446,866 (269)
Journal of Process Management. New Technologies, 2016 In accordance with the research conducted by Transparency International, in the period from 2009 until 2012, it is found that this European country did not undergo drastic changes during this period, when it comes to its ranking. According to this research, France belongs to the countries that undertake appropriate measures for the fight against ...
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Ticaret Mecmuasına Göre Suriye’nin İktisadi Yapısına Genel Bir Bakış 1925
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019 25 Nisan 1922 Milletler Cemiyeti’nin 22. Maddesine göre, 28 Nisan 1919 da kurulan mandat sistemine dayanarak Suriye ve onun bir bölümü olarak tanımlanan Lübnan, “A” türü manda Yamaç, 2018:1157 olarak Fransa’ya verilmiştir.
Gülin Öztürk, Aslıhan Nakiboğlu
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Research and Development Expenses under IFRS Mandatory Implementation: A Value Relevance Approach
Economic and Business Review, 2018 The paper focuses on the degree to which the accounting treatment of R&D expenditure is stock price informative following the adoption of IAS. Therefore, using recent data of French listed companies, starting from the year in which IFRS were applied ...
Hasna Chaibi
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Osmanlı Diplomasisinde “Musalahalar Devletler İledür” Kaidesi
Gazi Akademik Bakış, 2020 It is not possible to think of the experience of the Ottoman Empire in the field of Diplomacy apart from her adventure in the field of politics. Just as her political adventure was in a unique way, her experience in the field of diplomacy was likewise ...
Hilal ÇİFTÇİ
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source