Results 51 to 60 of about 1,480 (113)
ABSTRACT Background Older adults with osteosarcopenia, defined as the coexistence of osteopenia/osteoporosis and sarcopenia, have been associated with an increased risk of fractures compared with those with normal bone mineral density (BMD) and without sarcopenia.
Anjo Zhihui Lu +7 more
wiley +1 more source
Abstract Background Age‐related comorbidities occur earlier and more frequently in people with HIV (PWH) than in the general population and have emerged as a key challenge in long‐term HIV care. Unfortunately, many of these conditions remain undiagnosed, and systematic screening in clinical practice remains limited.
Anna Katrine Haslund Roed +4 more
wiley +1 more source
Diabetes and menopause: A critical yet neglected intersection
Diabetic Medicine, EarlyView.
Isabell Haage +3 more
wiley +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis
Objective Transition from long‐term denosumab (Dmab) to parathyroid hormone‐analogs or romosozumab (Romo) might expose patients to the risk of the so‐called rebound phenomenon. Adding Romo to Dmab might represent an option in patients experiencing a fracture while on Dmab.
Giovanni Adami +10 more
wiley +1 more source
Why Osteosarcopenia Matters: Clinical and Investigative Implications
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo +5 more
wiley +1 more source
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin +2 more
wiley +1 more source
FRAX (Australia) scores in women with impaired fasting glucose and diabetes
Background: Diabetes is associated with higher fracture risk despite higher bone mineral density (BMD), with FRAX® underestimating risk. This study aimed to investigate FRAX score with and without BMD for women with normoglycaemia, impaired fasting ...
Lelia L.F. de Abreu +4 more
doaj +1 more source
Ukrainian Version of FRAX: from Creation to Validation
FRAX® is an algorithm that computes 10-year probability of hip fracture and major osteoporotic fractures (hip, humerus, wrist fractures and clinical vertebral fractures) in patients aged 40 years and older. These probabilities are calculated based on age,
V.V. Povoroznуuk +4 more
doaj +1 more source
Fundamento y objetivos: Los estudios sobre validación del FRAX® en España muestran una infravaloración del riesgo de fracturas osteoporóticas principales (FOP) y predicciones más ajustadas para las fracturas femorales (FF).
Kanterewicz E +4 more
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