Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening
Abstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Maximilian Fröhlich +17 more
wiley +1 more source
Oxygen Fugacity Buffers and an Interactive Calculator
Abstract Oxygen fugacity buffers are equilibrium phase assemblages that constrain the chemical potential of oxygen. They may be coexisting minerals or fluids, or their metastable extrapolations. Oxygen fugacity values vary as a function of pressure and temperature, such that raw numbers often have little interpretive value.
Michael Anenburg
wiley +1 more source
A Hybrid ML‐PDE Framework for Predicting Breaking Ocean Waves
Abstract Wave breaking plays a central role in ocean dynamics, dissipating wave energy and shaping the evolution of the sea surface. Yet, breaking remains difficult to model: envelope‐based models efficiently capture nonlinear wave evolution and are interpretable but exclude breaking, while high‐fidelity direct numerical simulations resolve breaking ...
Y. Liu +3 more
wiley +1 more source
Protein kinase Cδ and pharmacomechanical coupling: Re‐envisioning cerebral vascular control
Abstract figure legend Top, G‐protein coupled receptors trigger electromechanical and pharmacomechanical coupling, the latter via signal transduction pathways that inhibit myosin light chain phosphatase. Middle, the relative contribution of electromechanical and pharmacomechanical coupling varies with the concentration and the vessel area to which ...
Nadia Haghbin +10 more
wiley +1 more source
Reconsidering Molecular Docking Practices in Aptamer Research
Benchmarking against the theophylline aptamer crystal structure shows that current docking workflows generate incorrect structures and fail to predict binding specificity, underscoring the need for caution when interpreting docking results in aptamer research. Molecular docking is increasingly used to infer aptamer–target interactions, yet most studies
Yachen Xie, Juewen Liu
wiley +1 more source
Sodiophilic mesoporous carbon confers a near‐perfect interface between Na metal and ceramic solid electrolytes, while serving as a host for solid Na anodes. This synergy forms a foundational element for sodium solid‐state batteries (Na‐SSBs) in pairing a dendrite‐resistant anode with an inherently (electro)chemically stable ceramic electrolyte.
J. Mark Weller +5 more
wiley +1 more source
Integrated optical phased arrays are emerging as scalable engines for solid‐state beam steering and programmable wavefront control. This Review maps the field from beam‐steering principles and core building blocks to material platforms, system‐level bottlenecks, and application frontiers, highlighting how heterogeneous integration, aperiodic ...
Jingwei Li +7 more
wiley +1 more source
Identification of the Parameters of the Szpica-Warakomski Method's Rectilinear Trend Complementary to the Gaussian Characteristic Area Method in the Functional Evaluation of Gas Injectors. [PDF]
Szpica D +5 more
europepmc +1 more source
6DOF Aircraft Landing Gear System with Magnetorheological Damper in Various Taxing and Touchdown Scenarios. [PDF]
Luong QV, Le QN, Hwang JH, Ho TM.
europepmc +1 more source
1D hydrogen engine modeling to investigate air-fuel ratio, spark timing, and water injection effects on performance and emissions. [PDF]
Saied OM, Abdelwahab M.
europepmc +1 more source

