Results 191 to 200 of about 11,868,774 (305)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Seroprevalence of <i>Toxoplasma</i> infection in free-range chickens in northeastern Libya. [PDF]

Open Vet J
Akra KMA, Awad HAA, Fitri LE, Sardjono TW, Sharif M.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Re-analysis with cage as the experimental unit: effect of feeding biochar, oat hulls, yeast fermentate, and organic acids on reduction of Campylobacter in free-range broilers from hatching to slaughter. [PDF]

Poult Sci
Takeuchi-Storm N, Dolcet-Negre MM, Calvo-Fernandez C, Jensen AN, Ravenni G, Sandberg M, Henriksen UB, Lassen B.   +7 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Pasture species selection for free-range egg production systems: Implications for laying performance, egg quality, hen welfare, and soil functioning. [PDF]

Poult Sci
Gandarillas M, López IF, Dörner J, Tadich T, Balocchi O, Guarda C.   +5 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Growth performance, carcass traits, and breast meat quality of slow-growing broiler strains reared in a free-range system: effects of genotype and sex at different slaughter ages. [PDF]

Trop Anim Health Prod
Lacerda MB, Valentim JK, de Almeida Torres Filho R, de Araújo CV, Silva RA, Romanelli EV, Boari CA, de Almeida AA, Pinheiro SRF.   +8 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Antimicrobial Susceptibility Profiles of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated From Intensively Reared and Free-Range Chickens in Selected Districts of Zambia. [PDF]

Vet Med Sci
Chawinga K, Hang'ombe BM, Mainda G, Mbaimbai F, Mataa L, Kabwali E, Goma FY, Muuka G, Munyeme M, Mkakosya RS, Shawa IT.   +10 more
europepmc   +1 more source