Results 101 to 110 of about 2,120,300 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Development and Contribution of Open Source Software Communities for the Library Progress in Indonesia

open access: yesRecord and Library Journal, 2019
Background of the study: Open source software is an open-based software and can be accessed for free. This open source software is growing rapidly at domestic and overseas. Many criteria are used by users.
Resty Jayanti Fakhlina   +1 more
doaj   +1 more source

Competing communities of users and developers of computer software: competition between open source software and commercial software [PDF]

open access: yes
The open source movement is a group of volunteer programmers that has recently caused quite a stir in the software market. The volunteers of this group develop computer operating systems, programming languages, and other software.
Berends,P., Wegberg,M.,van
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Software used for diploma thesis at Geoinformatics VSB-TUO

open access: yesGeoinformatics FCE CTU, 2007
The paper describes software usage for diploma thesis presented by VSB-TUO students during students conference GISáček. A prepared statistics was build from papers available at web pages of the conference.
Jan Růžička
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

FOSS Tools and Applications for Education in Geospatial Sciences

open access: yesISPRS International Journal of Geo-Information, 2017
While the theory and implementation of geographic information systems (GIS) have a history of more than 50 years, the development of dedicated educational tools and applications in this field is more recent.
Marco Ciolli   +7 more
doaj   +1 more source

A Developers Bill of Rights: What Open Source Developers Want in a Software License [PDF]

open access: yes
In this paper, we study open source developers' perspectives on the nature and structure of software licenses as well as the processes through which these licenses are designed.
MacCormack, Alan
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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