Results 101 to 110 of about 4,359,350 (361)

Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation. [PDF]

, 2019
In July 2018, the Food and Drug Administration warned about a possible relationship between dilated cardiomyopathy (DCM) in dogs and the consumption of dog food formulated with potatoes and pulse ingredients.
Adin, Alroy, Anna K Shoveller, Arslan, Avilés-Gaxiola, Backus, Baker, Baker, Bakker, Borgarelli, Butterwick, Bélanger, Cattanach, Christopher P F Marinangeli, Columbus, Daniel A Columbus, de Godoy, Degen, Dodd, Dutton, Fascetti, Flanagan, Freeman, Freeman, Freeman, Gloaguen, Greg Aldrich, Haber, Homann, Hoppel, Hou, Hurrell, Huxtable, Ito, Jennifer A Larsen, Johnson, Johnson, Kaplan, Kari J Ekenstedt, Keene, Kim, Kim, Kittleson, Ko, Kramer, Lien, Linder, Lynn Weber, Mansilla, Marinangeli, Maron, Marshall, Martin, Mathai, Menniti, Merheb, Meurs, Meurs, Moehn, Moise, Monnet, Nardelli, Nyachoti, Owczarek-Lipska, O’Máille, Patterson, Pion, Pion, Rice, Roberfroid, Robinson, Robinson, Răşanu, Sanderson, Sarah K Abood, Schaffer, Sisson, Spitze, Stoll, Story, Swanson, Teodorowicz, Tosh, Tôrres, Werner, Wilfredo D Mansilla, Worden, Yamka, Žilić   +88 more
core   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota [PDF]

, 2014
Dietary intake of L-carnitine can promote cardiovascular diseases in humans through microbial production of trimethylamine (TMA) and its subsequent oxidation to trimethylamine N-oxide (TMAO) by hepatic flavin-containing monooxygenases.
Bugg, Tim, Chen, Yin, Cosatti, Marialuisa, Jameson, Eleanor, Rajakumar, Kumar, Schäfer, Hendrik, Zhu, Yijun   +6 more
core   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Inhibited carnitine synthesis impairs adaptation to high-fat diet in Nile tilapia (Oreochromis niloticus)

Aquaculture Reports, 2020
High-fat diet (HFD) caused some adverse effects in farmed fish, thus the adaptation to HFD in fish is an important research topic. This study was conducted to examine the roles of carnitine and its related mitochondrial fatty acid β-oxidation (FAO) in ...
Ling-Yu Li, Jia-Min Li, Fang Qiao, Li-Qiao Chen, Mei-Ling Zhang, Zhen-Yu Du   +5 more
doaj   +1 more source

Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]

, 2015
Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S., Gumral, N., Karahan, N., Ozguner, M.F., Saygin, M., Çalişkan, Sadettin   +5 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Nutritional status and extended metabolic screening in Egyptian children with uncomplicated type 1 diabetes

Scientific Reports
Nutritional status assessment, including amino acids, carnitine, and acylcarnitine profile, is an important component of diabetes care management, influencing growth and metabolic regulation.
Hala M. Sakhr, Mohammed H. Hassan, Ahmed El-Abd Ahmed, Nagwan I. Rashwan, Rehab H. Abdel-Aziz, Amr S. Gouda, Rana Toghan   +6 more
doaj   +1 more source

CoA protects against the deleterious effects of caloric overload in Drosophila [PDF]

, 2016
We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes.
Baranski, Thomas J, Fink, Jill L, Musselman, Laura Palanker   +2 more
core   +2 more sources