Results 21 to 30 of about 43,342 (295)

Newborn Screening and Genetic Analysis Identify Six Novel Genetic Variants for Primary Carnitine Deficiency in Ningbo Area, China

Frontiers in Genetics, 2021
Primary carnitine deficiency (PCD) is an autosomal recessive disorder that could result in sudden death. It is caused by a defect in the carnitine transporter encoded by SLC22A5 (Solute Carrier Family 22 Member 5, MIM:603377).
Xiangchun Yang, Qiong Li, Fei Wang, Lulu Yan, Danyan Zhuang, Haiyan Qiu, Haibo Li, Liang Chen   +7 more
doaj   +1 more source

Clinical Effects of L-Carnitine Supplementation on Physical Performance in Healthy Subjects, the Key to Success in Rehabilitation: A Systematic Review and Meta-Analysis from the Rehabilitation Point of View

Journal of Functional Morphology and Kinesiology, 2021
L-carnitine supplementation improves body strength, sports endurance and exercise capacity, as well as delaying the onset of fatigue. The aim of this study was to identify the correct dosage of supplementation to obtain improvements in physical ...
Michele Vecchio, Rita Chiaramonte, Gianluca Testa, Vito Pavone   +3 more
doaj   +1 more source

Decreased Fasting Free Fatty Acids with L-Carnitine in Children with Carnitine Deficiency [PDF]

Pediatric Research, 1988
At the time of acute presentation, children with carnitine deficiency may have increased free fatty acid concentrations and hypoglycemia. However, whether carnitine replacement affects the plasma concentration of these substrates remains to be determined.
W F, Schwenk, D E, Hale, M W, Haymond
openaire   +2 more sources

Features of carnitine metabolism in young athletes

Спортивная медицина: наука и практика, 2023
Objective: to study the indicators of carnitine metabolism in young athletes of various specializations.Materials and methods: This study involved 46 people with different levels of physical activity aged 15 to 18 years.
A. S. Samoilov, A. V. Zholinsky, N. V. Rylova, I. V. Bolshakov   +3 more
doaj   +1 more source

Carnitine deficiency is associated with decreased exercise activity in hemodialysis patients

Renal Replacement Therapy, 2019
Background and aim Carnitine deficiency is common and associated with muscle atrophy in hemodialysis (HD) patients. We investigated whether carnitine levels could be an independent predictor for exercise capacity in these patients.
Junko Yano, Yusuke Kaida, Yosuke Nakayama, Sakuya Ito, Yuka Kurokawa, Nao Nakamura, Takuma Hazama, Takashi Maeda, Ryuki Hashida, Kyoko Tashiro, Takahiro Inokuchi, Hiroo Matsuse, Kei Fukami   +12 more
doaj   +1 more source

Decreased level of serum carnitine might lead to arteriosclerosis progression via the accumulation of advanced glycation end products in maintenance hemodialysis patients

Renal Replacement Therapy, 2017
Background Carnitine is reported to improve insulin resistance and reduce oxidative stress. Hyperglycemia and increased oxidative stress are well known to promote the production of advanced glycation end products (AGEs) that can lead to arteriosclerosis ...
Yumi Kamada, Takashi Masuda, Kazuhiko Kotani, Shinya Tanaka, Takeshi Nakamura, Nobuaki Hamazaki, Yoko Itoh, Ibuki Moriguchi, Naoyuki Kobayashi, Michihito Okubo, Kazuhiro Takeuchi, Shokichi Naito, Yasuo Takeuchi   +12 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Acute Exercise Stimulates Carnitine Biosynthesis and OCTN2 Expression in Mouse Kidney

Kidney & Blood Pressure Research, 2017
Background/Aims: Carnitine is essential for the transport of long-chain FAs (FA) into the mitochondria for energy production. During acute exercise, the increased demand for FAs results in a state of free carnitine deficiency in plasma.
Tom L. Broderick, Frank A. Cusimano, Chelsea Carlson, Leslie K. Tamura   +3 more
doaj   +1 more source

Primary carnitine deficiency in a neonate

Archives of Medicine and Health Sciences, 2021
Carnitine deficiency in paediatrics can present in infants with episodes of irritability, lethargy and hepatomegaly. The main treatment for primary carnitine deficiency is to take L-carnitine supplements.
Manish Rasania, Naveed Majid Ahmed, Bhatt Vivek Prafulchandra, Shashank Jain   +3 more
doaj   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source