Results 41 to 50 of about 43,342 (295)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa [PDF]

Human Reproduction Update, 1996
Spermatozoa are produced in the testis and undergo post-gonadal modifications in the epididymis to acquire fertilizing ability. In epididymal plasma, high-molecular-weight proteins and such small molecules as free-L carnitine convert the gametes into "competent' and functional cells.
C, Jeulin, L M, Lewin
openaire   +2 more sources

Impaired acylcarnitine profile in transfusion-dependent beta-thalassemia major patients in Bangladesh

Journal of Advanced Research, 2018
Patients with beta-thalassemia major (BTM) suffer from fatigue, poor physical fitness, muscle weakness, lethargy, and cardiac complications which are related to an energy crisis.
Suprovath Kumar Sarker, Md Tarikul Islam, Golam Sarower Bhuyan, Nusrat Sultana, Mst. Noorjahan Begum, Mohammad Al Mahmud-Un-Nabi, Md. Abdulla Al Noman Howladar, Tashmim Farhana Dipta, A.K.M. Muraduzzaman, Syeda Kashfi Qadri, Tahmina Shirin, Salma Sadiya, Manzoor Hussain, Waqar Ahmed Khan, Sharif Akhteruzzaman, Syed Saleheen Qadri, Firdausi Qadri, Kaiissar Mannoor   +17 more
doaj   +1 more source

Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency

Molecular Genetics and Metabolism Reports, 2014
Background: The prevalence of primary carnitine deficiency (PCD) in the Faroe Islands is the highest reported in the world (1:300). Serious symptoms related to PCD, e.g.
Jan Rasmussen, Allan M. Lund, Lotte Risom, Flemming Wibrand, Hannes Gislason, Olav W. Nielsen, Lars Køber, Morten Duno   +7 more
doaj   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Plasma free and total carnitine measured in children by tandem mass spectrometry

Brazilian Journal of Medical and Biological Research, 2002
Free and total carnitine quantification is important as a complementary test for the diagnosis of unusual metabolic diseases, including fatty acid degradation disorders.
J.H. Osorio, M. Pourfarzam
doaj   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Association between carnitine deficiency and the erythropoietin resistance index in patients undergoing peritoneal dialysis: a cross-sectional observational study

Renal Failure, 2020
Carnitine deficiency contributes to developing various pathological conditions, such as cardiac dysfunction, muscle weakness, and erythropoietin-resistant anemia in patients undergoing hemodialysis.
Shohei Kaneko, Keiji Hirai, Junki Morino, Saori Minato, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Yuichiro Ueda, Kiyonori Ito, Susumu Ookawara, Yoshiyuki Morishita   +15 more
doaj   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise?

Molecules, 2020
l-Carnitine is an amino acid derivative widely known for its involvement in the transport of long-chain fatty acids into the mitochondrial matrix, where fatty acid oxidation occurs.
Antonio Gnoni, Serena Longo, Gabriele V. Gnoni, Anna M. Giudetti   +3 more
doaj   +1 more source