Results 131 to 140 of about 11,330,773 (285)
Sustainable FuturesThe shipping industry is currently the sixth largest contributor to global emissions, responsible for one billion tons of greenhouse gas emissions. Urgent action is needed to achieve carbon neutrality in the shipping industry for sustainability.
Enna Hirata +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
ComputersStartups face critical challenges in prioritizing requirements under severe resource constraints. Although methods such as RICE and ICE are known, prior studies show that decisions often default to ad hoc judgments and stakeholder opinions.
Frédéric Pattyn +4 more
doaj +1 more source
Finding free bioinformatics data
, 2004 Steve Buckingham, Data's Future Shock, Nature 428, 774 (15 April 2004). Nature's technology feature focuses on bioinformatics data sources, and features a sidebar "Exploring the public domain," which documents freely-available resources including journals such as the Nucleic Acids Research database issue and the variety
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
European Respiratory ReviewBackground Chronic respiratory diseases, such COPD and asthma, increase the risk of atherosclerotic cardiovascular disease (ASCVD) through shared pathophysiological mechanisms and modifiable risk factors.
Omer Faruk Uysal +10 more
doaj +1 more source