Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review. [PDF]
JMIR Med Inform, 2022 MacKenna B +11 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Columbus Free Press staff members
, 1990 Photograph of two staff members of the Free Press newspaper in Columbus, Ohio, wearing t-shirts advertising the publication. They are identified on the reverse as "J. B. and D. J." . The Columbus Free Press began as a bi-weekly publication in Columbus,
Columbus Free Press (Publisher)
core
In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions. [PDF]
Proteomics, 2023 Bons J +6 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Contrast sensitivity perimetry data from adults free of eye disease
Data in Brief, 2016 This data article contains data referenced in “Individual Differences in the Shape of the Nasal Visual Field” [1]. The data were gathered from volunteers free of eye disease ages 21–85 who were tested with Contrast Sensitivity Perimetry (CSP), which uses
William H. Swanson +3 more
doaj +1 more source
MaxDIA enables library-based and library-free data-independent acquisition proteomics. [PDF]
Nat Biotechnol, 2021 Sinitcyn P +17 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Addressing hospitalisations with non-error-free data by generalised SEIR modelling of COVID-19 pandemic. [PDF]
Sci Rep, 2021 Mendes JM, Coelho PS.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source