Results 31 to 40 of about 27,391 (261)

Low emittance injector design for free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2015
Several parameters determine the performance of free electron lasers: the slice and the projected emittance, the slice energy spread, and the peak current are the most crucial ones.
S. Bettoni, M. Pedrozzi, S. Reiche
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Free electron laser.

The Review of Laser Engineering, 1987
Concepts and historical review of free electron laser are reported. Since the experiment at Stanford University was successful in 1977, great numberof FEL experiments with various accelerators were successfully performed to observe amplification and oscillation of radiations in the wavelength range of 0.5 μm-103μm.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Laser phase errors in seeded free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2012
Harmonic seeding of free electron lasers has attracted significant attention as a method for producing transform-limited pulses in the soft x-ray region. Harmonic multiplication schemes extend seeding to shorter wavelengths, but also amplify the spectral
D. Ratner, A. Fry, G. Stupakov, W. White
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Real-time tracking of the intramolecular vibrational dynamics of liquid water

Communications Chemistry
Water’s polarity and hydrogen-bond network give rise to its unique chemical and biochemical behaviour. Its vibrational motions, occurring on a few-femtosecond timescale, govern ultrafast energy transfer within the hydrogen-bond network.
Gaia Giovannetti, Sergey Ryabchuk, Ammar Bin Wahid, Hui-Yuan Chen, Giovanni Batignani, Erik P. Månsson, Oliviero Cannelli, Emanuele Mai, Andrea Trabattoni, Ofer Neufeld, Angel Rubio, Vincent Wanie, Hugo Marroux, Tullio Scopigno, Majed Chergui, Francesca Calegari   +15 more
doaj   +1 more source

Formation of electron bunches for harmonic cascade x-ray free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2006
Specific requirements for the electron beam in harmonic cascade-free electron lasers, together with means to produce such beams, are presented. All results are illustrated with simulations and particle tracking studies.
M. Cornacchia, S. Di Mitri, G. Penco, A. A. Zholents   +3 more
doaj   +1 more source

Radio-Frequency Undulators, Cyclotron Auto Resonance Maser and Free Electron Lasers

Applied Sciences, 2021
We discuss a hybrid Free Electron Laser (FEL) architecture operating with a RF undulator provided by a powerful Cyclotron Auto-Resonance Maser (CARM). We outline the design elements to operate a compact X-ray device.
Emanuele Di Palma, Silvio Ceccuzzi, Gian Luca Ravera, Elio Sabia, Ivan Spassovsky, Giuseppe Dattoli   +5 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source