Results 91 to 100 of about 1,634,788 (236)
Free-energy Minimization and The Dark Room Problem
Frontiers in Psychology, 2012 Recent years have seen the emergence of an important new fundamental theory of brain function. This theory brings information-theoretic, Bayesian, neuroscientific, and machine learning approaches into a single framework whose overarching principle is the
Karl eFriston +2 more
doaj +1 more source
Free Energy and the Generalized Optimality Equations for Sequential Decision Making
, 2012 The free energy functional has recently been proposed as a variational principle for bounded rational decision-making, since it instantiates a natural trade-off between utility gains and information processing costs that can be axiomatically derived ...
Braun, Daniel A., Ortega, Pedro A.
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Quenched Point-to-Point Free Energy for Random Walks in Random Potentials [PDF]
, 2013 We consider a random walk in a random potential on a square lattice of arbitrary dimension. The potential is a function of an ergodic environment and some steps of the walk.
Rassoul-Agha, Firas, Seppäläinen, Timo
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
A Measure of Information Available for Inference
Entropy, 2018 The mutual information between the state of a neural network and the state of the external world represents the amount of information stored in the neural network that is associated with the external world.
Takuya Isomura
doaj +1 more source
Recognition Dynamics in the Brain under the Free Energy Principle [PDF]
Neural Computation, 2018 Abstract We formulate the computational processes of perception in the framework of the principle of least action by postulating the theoretical action as a time integral of the variational free energy in the neurosciences. The free energy principle is accordingly rephrased, on autopoetic grounds, as follows: all viable organisms attempt
openaire +4 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks
NeuroImage: Clinical, 2017 In this opinion paper, we describe a combined view of functional and effective brain connectivity along with the free-energy principle for investigating persistent disruptions in brain networks of patients with focal epilepsy.
Amir Omidvarnia +4 more
doaj +1 more source