Results 81 to 90 of about 10,102,387 (234)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Modeling of a Neural System Based on Statistical Mechanics
Entropy, 2018 The minimization of a free energy is often regarded as the key principle in understanding how the brain works and how the brain structure forms. In particular, a statistical-mechanics-based neural network model is expected to allow one to interpret many ...
Myoung Won Cho, Moo Young Choi
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Free-energy Minimization and The Dark Room Problem
Frontiers in Psychology, 2012 Recent years have seen the emergence of an important new fundamental theory of brain function. This theory brings information-theoretic, Bayesian, neuroscientific, and machine learning approaches into a single framework whose overarching principle is the
Karl eFriston +2 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
, 1993 Recently, a generalized kinetic model for silicide formation has been developed and a principle of the largest free energy degradation rate (largest FEDR) has been proposed.
Lin Zhang, Douglas G. Ivey
core +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
, 2014 Cartoon representation of the relative free energy for CYP2A6-APAP metabolism according to the Curtin-Hammett principle.
Yue Yang (52715) +2 more
core +1 more source
Recognition Dynamics in the Brain under the Free Energy Principle [PDF]
Neural Computation, 2018 Abstract We formulate the computational processes of perception in the framework of the principle of least action by postulating the theoretical action as a time integral of the variational free energy in the neurosciences. The free energy principle is accordingly rephrased, on autopoetic grounds, as follows: all viable organisms attempt
openaire +4 more sources