Results 81 to 90 of about 1,634,788 (236)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Universal Optimism of the Self-Evidencing Mind

Entropy
Karl Friston’s free-energy principle casts agents as self-evidencing through active inference. This implies that decision-making, planning and information-seeking are, in a generic sense, ‘wishful’.
Elizabeth L. Fisher, Jakob Hohwy
doaj   +1 more source

Modeling of a Neural System Based on Statistical Mechanics

Entropy, 2018
The minimization of a free energy is often regarded as the key principle in understanding how the brain works and how the brain structure forms. In particular, a statistical-mechanics-based neural network model is expected to allow one to interpret many ...
Myoung Won Cho, Moo Young Choi
doaj   +1 more source

The Hardy Uncertainty Principle Revisited

, 2010
We give a real-variable proof of the Hardy uncertainty principle. The method is based on energy estimates for evolutions with positive viscosity, convexity properties of free waves with Gaussian decay at two different times, elliptic $L^2$-estimates and ...
Cowling, M., Escauriaza, L., Kenig, C. E., Ponce, G., Vega, L.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Kinetic Energy and the Free Energy Principle in the Birth of Human Life

Reproductive Medicine
The retrospective noninterventional study investigated the kinetic energy of video images of 18 fertilized eggs (7 were normal and 11 were abnormal) recorded by a time-lapse device leading up to the beginning of the first cleavage.
Yasunari Miyagi, Yasuyuki Mio, Keitaro Yumoto, Rei Hirata, Toshihiro Habara, Nobuyoshi Hayashi   +5 more
doaj   +1 more source

Cultured Cortical Neurons Can Perform Blind Source Separation According to the Free-Energy Principle. [PDF]

PLoS Computational Biology, 2015
Blind source separation is the computation underlying the cocktail party effect--a partygoer can distinguish a particular talker's voice from the ambient noise.
Takuya Isomura, Kiyoshi Kotani, Yasuhiko Jimbo   +2 more
doaj   +1 more source

Effect of the Minimal Length on Bose-Einstein Condensation in the Relativistic Ideal Bose Gas

, 2014
Based on the generalized uncertainty principle (GUP), the critical temperature and the Helmholtz free energy of Bose-Einstein condensation (BEC) in the relativistic ideal Bose gas are investigated. At the non-relativistic limit and the ultra-relativistic
Tian, Chi, Zhang, Xiuming
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source