Results 61 to 70 of about 5,826,146 (302)

Depth-Dependent Adsorbed–Free Methane Partitioning and Deep CBM Enrichment in the Daning–Jixian Block, Ordos Basin

open access: yesEnergies
Coal reservoirs commonly contain both adsorbed and free methane, but their depth-dependent partitioning and controlling mechanisms remain difficult to quantify.
Longmei Zhao   +8 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

open access: yesFEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

A geophysical study of a pockmark in the Nyegga region, Norwegian Sea [PDF]

open access: yes, 2008
Over the last decade pockmarks have proven to be important seabed features that provideinformation about fluid flow on continental margins. Their formation and dynamics are stillpoorly constrained due to the lack of proper three dimensional imaging of ...
Ker, S.   +20 more
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Recoil Free Scattering From a Free Gas

open access: yes, 2008
9 pages, 2 ...
Sanders, Scott N.   +2 more
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Slow Dynamics of Hydrate Systems Revealed by a Double BSR

open access: yesGeophysical Research Letters
Determining how gas hydrate distribution evolved along continental margins in the past is essential to understanding its evolution in the future. Moreover, hydrate decomposition has been linked to several catastrophic events, including some of the ...
M. Fabre   +7 more
doaj   +1 more source

Characteristics of occurrence and distribution rule of deep coalbed methane in supercritical state

open access: yesMeitan kexue jishu
Deep Coalbed methane(CBM) has become an important direction for gas storage and production, but its original occurrence state of adsorbed gas and free gas and distribution law under different geological conditions are unclear, which restricts the ...
Lihong ZHOU   +7 more
doaj   +1 more source

Validation of Patient‐Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis

open access: yesArthritis Care &Research, EarlyView.
Objective To assess the validity of the Patient‐Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). Methods Within the longitudinal patient registry of CNO, English‐speaking patients aged 8 years and older self‐reported PROMIS Pediatric measures of fatigue, pain ...
Mary M. Eckert   +43 more
wiley   +1 more source

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