Results 71 to 80 of about 154,233 (325)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Automatic Manipulation of Magnetically Actuated Helical Microswimmers in Static Environments
Micromachines, 2018 Electromagnetically actuated microswimmers have been widely used in various biomedical applications due to their minor invasive traits and their easy access to confined environments.
Jia Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
NECSUS, 2012 In October 2011, the British artist Tacita Dean presented her work FILM at the Tate Modern in London. Dean’s installation is a film short projected in a continuous loop onto a large screen in a dark space furnished with seats for visitors.
Francesco Casetti
doaj +1 more source
An effective model for the quantum Schwarzschild black hole
Physics Letters B, 2022 We present an effective theory to describe the quantization of spherically symmetric vacuum motivated by loop quantum gravity. We include anomaly-free holonomy corrections through a canonical transformation and a linear combination of constraints of ...
Asier Alonso-Bardaji +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Minimal Model of the Free Loop Space [PDF]
, 2012 El primer objetivo de este trabajo es dotar de una estructura diferencial al espacio de lazos libres de una variedad cerrada simplemente conexa y a partir de esto se definirá el dual del producto de lazos.
Duarte Vogel, Diego Daniel
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Loop I/NPS Morphology Predictions in the Ultralong-wavelength Band
The Astrophysical JournalLoop I/North Polar Spur (NPS) is the giant arc structure above the Galactic plane observed at radio wavelengths (≲10 GHz). There has been long-standing debate about its origin. While many people believe that it consists of nearby supernova remnants (SNRs)
Yanping Cong +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source