Results 91 to 100 of about 689,139 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Free movement in the European Union: the case of Great Britain

open access: yesHalyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2016
In this paper the authors consider the free movement of goods, services and capital within the European Union as a case of the Great Britain. Also, an article devoted to the role of Britain in the European Union, addresses the issue of EU enlargement in
Е. Chukubayev
doaj  

National E-Systems for Combating VAT Evasion and Intra-EU Trade. Hungary’s ‘EAKER’ and Romania’s ‘RO e-Transport’

open access: yesEuropean Papers
(Series Information) European Papers - A Journal on Law and Integration, 2025 10(1), 55-96 | Article | (Table of Contents) 1. Introduction. – 2. A quick look at border and other types of checks. – 3. An overview of the two systems. – 3.1. Hungary’s EKAER.
Szilárd Gáspár-Szilágyi   +1 more
doaj   +1 more source

Europäisch-türkische Warenverkehrsfreiheit

open access: yesTürk-Alman Üniversitesi Hukuk Fakültesi Dergisi, 2022
„Man verliebt sich nicht in einen Binnenmarkt ohne Grenzen“ – sagte der langjährige EU-Kommissionspräsident Jacques Delors. Dabei ist der gemeinsame Markt durch freien Warenverkehr politisch „eine der Erfolgsgeschichten des europäischen Einigungswerks ...
Thomas Wilrich
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

The influence of Free-Trade on the environmental effects of transportation. Scale-, Technique- and Composition-Effects [PDF]

open access: yes, 2007
The changeover from a situation of Autarky to a situation of Free- Trade alters the trade and production patterns of the participating countries which in turn affects the transportation-sector.
Vannoni, Stefan
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Fine-tuning the Jurisprudence: The ECJ's Judicial Activism and Self-restraint [PDF]

open access: yes
Legal and political science scholars omit an important variable in explaining compliance with ECJ rulings: the fine-tuning in the follow-up cases. This paper shows with the Kohll/Decker social policy jurisprudence that, first, the Court applied the ...
Andreas J. Obermaier
core  

Financial market integration in the EU: A practical inventory of benefits and hurdles in the Single Market [PDF]

open access: yes, 2019
It is 25 years since the European Union (EU) agreed to complete the European Single Market (SM) in goods, ser- vices, people, and capital. While many barriers to the free movement of capital across borders have been removed, some important practical ...
Gnath, Katharina   +5 more
core  

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