Results 81 to 90 of about 18,052 (297)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Horizontal direct effect and the free movement of goods [PDF]

, 2011
Die Frage, ob Privatpersonen unmittelbar an die Europäischen Grundfreiheiten gebunden sind, die Frage also ob diese Bestimmungen unmittelbare Drittwirkung entfalten, wurde in den letzten Jahren intensiv und kontroversiell diskutiert.
Krenn, Christoph
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ROMANIAN SOCIAL MOVEMENT: BETWEEN REPOLITICIZATION AND REINFORCEMENT OF THE STATUS-QUO (2012-2017)

Studia Universitatis Babeş-Bolyai. Studia Europaea, 2017
The article states that the social movement that emerged in Romania in 2012 is part of the global anti-austerity movement. It proposes the movement’s analysis in the key of Karl Polanyi’s theory of double movement, portraying it as a counter-movement ...
Victoria STOICIU
doaj   +1 more source

Prptection of intellectual property rights and restriction of free movement of goods [PDF]

, 2012
Viens no svarīgākajiem brīvas preču aprites ierobežojumu attaisnojumiem, kas noteikts Līgumā par Eiropas Savienības darbību, ir industriālā un komerciālā īpašuma aizsardzība.
Putna, Krista
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Trade in services of member states of the Eurasian Economic Union

RUDN Journal of Economics, 2019
The Treaty on the Eurasian Economic Union, which became effective since January 1, 2015, establishes the principles and the purposes of integration consolidation and also provides free movement of goods, services, the capital and labor power in the ...
Kuanysh N. Yelikbaev
doaj   +1 more source

Blurring the boundaries of the free movement of goods: opinion of advocate general Slynn in Cinéthèque [PDF]

, 2022
Article 34 TFEU (Article 30 EEC, when this case was decided) prohibits quantitative restrictions on import (ie bans or quotas) and measures having equivalent effect on quantitative restrictions on imports.
Spaventa, Eleanor
core