Results 91 to 100 of about 18,052 (297)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Investigate of goods free movement assurance in EC countries [PDF]

open access: yes, 2010
Bakalaura darba mērķis ir noskaidrot kā notiek brīvā preču kustība EK valstīs, noskaidrot būtiskākos preču kustības aspektus, izpētīt tirgus uzraudzību Latvijā, atklāt problēmas un dod priekšlikumus problēmu risināšanā.
Pontaga, Inese
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

National E-Systems for Combating VAT Evasion and Intra-EU Trade. Hungary’s ‘EAKER’ and Romania’s ‘RO e-Transport’

open access: yesEuropean Papers
(Series Information) European Papers - A Journal on Law and Integration, 2025 10(1), 55-96 | Article | (Table of Contents) 1. Introduction. – 2. A quick look at border and other types of checks. – 3. An overview of the two systems. – 3.1. Hungary’s EKAER.
Szilárd Gáspár-Szilágyi   +1 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Free movement in the European Union: the case of Great Britain

open access: yesHalyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2016
In this paper the authors consider the free movement of goods, services and capital within the European Union as a case of the Great Britain. Also, an article devoted to the role of Britain in the European Union, addresses the issue of EU enlargement in
Е. Chukubayev
doaj  

Europäisch-türkische Warenverkehrsfreiheit

open access: yesTürk-Alman Üniversitesi Hukuk Fakültesi Dergisi, 2022
„Man verliebt sich nicht in einen Binnenmarkt ohne Grenzen“ – sagte der langjährige EU-Kommissionspräsident Jacques Delors. Dabei ist der gemeinsame Markt durch freien Warenverkehr politisch „eine der Erfolgsgeschichten des europäischen Einigungswerks ...
Thomas Wilrich
doaj  

The free movement of goods and the protection of health in the EU [PDF]

open access: yes
The free movement of goods is one of the fundamental principles of the European Union (EU) and is enshrined in the Treaty on the Functioning of the European Union (TFEU).
Forsang, Georgiana
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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